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Z0877

Zotepine

Name: Zotepine
Brand: SIGMA

Synonym(s):

2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₈ClNOS

CAS Number:

26615-21-4

Molecular Weight:

331.86

NACRES:

NA.77

PubChem Substance ID:

329831602

UNSPSC Code:

12352200

MDL number:

MFCD00868143

Assay:

>98% (HPLC)

Form:

powder

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Properties

assay

>98% (HPLC)

Quality Segment

100

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL

originator

Astellas

storage temp.

room temp

SMILES string

CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3

InChI key

HDOZVRUNCMBHFH-UHFFFAOYSA-N

Description

Application

Zotepine has been used as an anti-psychotic agent:

in biophysical studies with serotonin 2A receptor (5-HT_2AR)
to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)
to study its protective effects on the human embryonic kidney (HEK cells)

Biochem/physiol Actions

Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT_2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.

Zotepine is an atypical antipsychotic.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

GHS07,GHS09

Signal Word

Warning

Hazard Codes

H302,H410

Precautionary Statements

P264 - P270 - P273 - P301 + P312 - P391 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)