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Merck
CN

Z4277

Zileuton

≥98% (HPLC), 5-Lipoxygenase inhibitor, powder

Synonym(s):

(±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea

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About This Item

Empirical Formula (Hill Notation):
C11H12N2O2S
CAS Number:
111406-87-2
Molecular Weight:
236.29
UNSPSC Code:
12352200
PubChem Substance ID:
329831613
NACRES:
NA.77
MDL number:
MFCD00866097
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Product Name

Zileuton, ≥98% (HPLC)

SMILES string

CC(N(O)C(N)=O)c1cc2ccccc2s1

InChI key

MWLSOWXNZPKENC-UHFFFAOYSA-N

InChI

1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL at ~60 °C (warm up to 60 C for 5min)

originator

Abbott

storage temp.

room temp

Quality Level

100

Gene Information

human ... ALOX5(240)

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Biochem/physiol Actions

Zileuton is a 5-Lipoxygenase inhibitor.
Zileuton is an anti-asthmatic, an inhibitor of 5-lipoxygenase; the initial enzyme in the biosynthesis of leukotrienes from arachidonic acid.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000463927
0000463927
0000243599
0000243599
0000220964

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Norwin Kubick et al.
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Diabetic retinopathy (DR) is a devastating disease leading to blindness among majority of working adults around the globe. Nonetheless, an effective treatment or cure for the disease is still to be achieved. This is because the cellular and molecular mechanisms
Kaneez Fatima et al.
Frontiers in nutrition, 9, 857256-857256 (2022-04-26)
Carvacrol, a monoterpene known for its pharmacological activities, is present in the essential oil of Origanum majorana, Origanum vulgare, Thymus vulgaris, and Lippia graveolens. It is used in food as a flavoring and preservative agent in cosmetics and medicines because
Ju Youn Lee et al.
Nature communications, 11(1), 2358-2358 (2020-05-14)
Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer's disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) is first generated
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