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00922

Difluoroacetic acid

for LC-MS LiChropur™, ≥97.5% (GC)

Synonym(s):

DFA

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About This Item

Linear Formula:
F2CHCO2H
CAS Number:
381-73-7
Molecular Weight:
96.03
UNSPSC Code:
41116004
NACRES:
NB.21
MDL number:
MFCD00004220
Beilstein/REAXYS Number:
1098588
eCl@ss:
32120505
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Quality Segment

assay

≥97.5% (GC), 97.5-102.5% (T)

technique(s)

HPLC: suitable, LC/MS: suitable, ion chromatography: suitable

refractive index

n20/D 1.344 (lit.)

bp

132-134 °C (lit.)

mp

−1 °C (lit.)

density

1.526 g/mL at 25 °C (lit.)

cation traces

Al: ≤5 ppm, Ca: ≤20 ppm, Cu: ≤5 ppm, Fe: ≤2 ppm, K: ≤50 ppm, Mg: ≤5 ppm, Na: ≤50 ppm

suitability

passes test for LC-MS

SMILES string

OC(=O)C(F)F

InChI

1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

PBWZKZYHONABLN-UHFFFAOYSA-N

General description

Compared to trifluoroacetic acid (TFA), difluoroacetic acid (DFA) exhibits an improved sensitivity in mass spectral detection (ESI) as it has a reduced effect on ion suppression in reversed-phase liquid chromatography (RPLC-MS), while keeping its strong chromatographic performance enhancing effects.

Difluoroaceticacid is used in liquid chromatography-mass spectrometry applications. It is a volatile, low molecular-weight organic acid that improves the ionization and resolution of many molecules.

Application

Difluoroacetic acid can be used as an:
  • Acidifier in liquid chromatography (LC) experiments.
  • Ion-pairing agent in the HILIC-MS (hydrophilic interaction liquid chromatography-mass spectrometry) analysis of intact pharmaceutical glycoproteins.

Other Notes

Discover LiChropur™ reagents ideal for HPLC or LC-MS analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Codes

H314,H332,H412

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class

8A - Combustible corrosive hazardous materials

Flash Point (°F)

172.4 °F - closed cup

Flash Point (°C)

78 °C - closed cup

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