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Merck
CN

40458

1-Nitrosopiperidine solution

certified reference material, 5000 μg/mL in methanol

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About This Item

CAS Number:
100-75-4
MDL number:
MFCD00023652
UNSPSC Code:
41116105
NACRES:
NA.24

Key Documents

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Product Name

1-Nitrosopiperidine solution, certified reference material, 5000 μg/mL in methanol

SMILES string

N1(CCCCC1)N=O

InChI

1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2

InChI key

UWSDONTXWQOZFN-UHFFFAOYSA-N

grade

certified reference material
TraceCERT®

product line

TraceCERT®

CofA

current certificate can be downloaded

packaging

ampule of 1 mL

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

concentration

5000 μg/mL in methanol

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

environmental

format

single component solution

storage temp.

2-8°C

Quality Level

300

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Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Application

1-Nitrosopiperidine solution may be used as an analytical reference standard for the determination of nitrosamine impurities in pharmaceutical preparations using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
1-Nitrosopiperidine solution is commonly employed as a certified reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with  ISO 17034 and  ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kinetics of the oxidation of N-aminopiperidine with chloramine
Darwich.Ch, et al.
Kinetics and Catalysis, 50, 103-110 (2009)
Simultaneous analysis of carcinogenic N-nitrosamine impurities in metformin tablets using on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry
Ishizaki A, et al.
Journal of Chromatography A, 1710, 464416-464416 (2023)
Kinetics of the oxidation of N-aminopiperidine with chloramine
Darwich.Ch, et al.
Kinetics and Catalysis, 50(1), 103-110 (2009)
Hansen L Wong et al.
Chemical research in toxicology, 16(10), 1298-1305 (2003-10-21)
N-Nitrosopiperidine (NPIP) is a potent rat nasal carcinogen whereas N-nitrosopyrrolidine (NPYR), a hepatic carcinogen, is weakly carcinogenic in the nose. NPIP and NPYR may be causative agents in human cancer. P450-catalyzed alpha-hydroxylation is the key activation pathway by which these
I T Vermeer et al.
Mutation research, 428(1-2), 353-361 (1999-10-13)
Many constituents present in the human diet may inhibit endogenous formation of N-nitroso compounds (NOC). Studies with human volunteers showed inhibiting effects of intake of ascorbic acid and green tea consumption on nitrosation using the N-nitrosoproline test. The aim of
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