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Merck
CN

40458

Supelco

1-Nitrosopiperidine solution

certified reference material, 5000 μg/mL in methanol

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About This Item

CAS Number:
100-75-4
MDL number:
MFCD00023652
UNSPSC Code:
41116105

Key Documents

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grade

certified reference material
TraceCERT®

Quality Level

300

product line

TraceCERT®

CofA

current certificate can be downloaded

packaging

ampule of 1 mL

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

concentration

5000 μg/mL in methanol

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

environmental

format

single component solution

storage temp.

2-8°C

SMILES string

N1(CCCCC1)N=O

InChI

1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2

InChI key

UWSDONTXWQOZFN-UHFFFAOYSA-N

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General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
1-Nitrosopiperidine solution is commonly employed as a certified reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices

Application

1-Nitrosopiperidine solution may be used as an analytical reference standard for the determination of nitrosamine impurities in pharmaceutical preparations using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with  ISO 17034 and  ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kinetics of the oxidation of N-aminopiperidine with chloramine
Darwich.Ch, et al.
Kinetics and Catalysis, 50, 103-110 (2009)
Kinetics of the oxidation of N-aminopiperidine with chloramine
Darwich.Ch, et al.
Kinetics and Catalysis, 50(1), 103-110 (2009)
Simultaneous analysis of carcinogenic N-nitrosamine impurities in metformin tablets using on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry
Ishizaki A, et al.
Journal of Chromatography A, 1710, 464416-464416 (2023)
Hansen L Wong et al.
Chemical research in toxicology, 16(10), 1298-1305 (2003-10-21)
N-Nitrosopiperidine (NPIP) is a potent rat nasal carcinogen whereas N-nitrosopyrrolidine (NPYR), a hepatic carcinogen, is weakly carcinogenic in the nose. NPIP and NPYR may be causative agents in human cancer. P450-catalyzed alpha-hydroxylation is the key activation pathway by which these
Samuel González-Mancebo et al.
Mutation research, 558(1-2), 45-51 (2004-03-24)
The genotoxicity of nitrosopiperidine and six alkyl derivatives was studied by use of the Ames tester strains TA100 and TA1535 in the pre-incubation method. Among the compounds investigated, those exhibiting genotoxic activity under the experimental conditions employed were only genotoxic
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