Skip to Content
Merck
CN

Key Documents

View All Documentation

442641

Methapyrilene HCl

analytical standard

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

CAS Number:
135-23-9
UNSPSC Code:
12352200
PubChem Substance ID:
24867939
EC Number:
205-184-8
MDL number:
MFCD00050665
NACRES:
NA.24
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

grade

analytical standard

Quality Level

100

CofA

current certificate can be downloaded

packaging

ampule of 1000 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-30°C

SMILES string

CN(C)CCN(CC1=CC=CS1)C2=NC=CC=C2.Cl

InChI

1S/C14H19N3S.ClH/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14;/h3-8,11H,9-10,12H2,1-2H3;1H

InChI key

BONORRGKLJBGRV-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

General description

Methapyrilene is an H1-receptor antihistamine that is known to cause periportal hepatic necrosis following acute high dose administration to the rat subjects in in vitro studies carried out for the identification of mutagens and/or carcinogens.

Application

Methapyrilene HCl may be used as an analytical reference standard for the determination of the analyte in animal feed, human urine and wastewater by high-performance liquid chromatography (HPLC) and gas chromatography (GC) techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Still not finding the right product?

Explore all of our products under Methapyrilene HCl

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAE1513
LRAD5761
LRAC8592
LC23583V
LC22072V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

LC-MS Analysis of Serum for a Wide Analyte Range Using a Novel HLB SPE Phase

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation.
Ratra GS, et al.
Chemico-Biological Interactions, 129(3), 279-295 (2000)
Trace analysis of the antihistamines methapyrilene hydrochloride, pyrilamine maleate and triprolidine hydrochloride monohydrate in animal feed, human urine and wastewater by high-performance liquid chromatography and gas chromatography with nitrogen-phosphorus detection.
Thompson Jr HC and Holder CL
Journal of Chromatography A, 283(3), 251-264 (1984)

Global Trade Item Number

SKUGTIN
44264104061834420590