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Merck
CN

48599

2,3,7,8-Tetrachlorodibenzo-p-dioxin solution

analytical standard

Synonym(s):

2,3,7,8-TCDD

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About This Item

CAS Number:
1746-01-6
UNSPSC Code:
12352200
EC Number:
203-625-9

Key Documents

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InChI key

HGUFODBRKLSHSI-UHFFFAOYSA-N

InChI

1S/C12H4Cl4O2/c13-5-1-9-10(2-6(5)14)18-12-4-8(16)7(15)3-11(12)17-9/h1-4H

grade

analytical standard

CofA

current certificate can be downloaded

packaging

ampule of 1 mL

storage temp.

2-8°C

General description

2,3,7,8-Tetrachlorodibenzo-p-dioxin is a highly distributed environmental contaminant, released by industrial activities, which can act like as a reproductive toxicant and endocrine disruptor in all vertebrates.
2,3,7,8-Tetrachlorodibenzo-p-dioxin is the most potent congener of dioxins and dioxin-like chemicals, which can exert adverse effects in laboratory animals used in testing.

Application

2,3,7,8-Tetrachlorodibenzo-p-dioxin solution has been used as standard in investigating the effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin to offsprings of fish, using high performance gas chromatography coupled with high performance mass spectrometry (HPGC-HPMS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

signalword

Danger

Hazard Classifications

Aquatic Chronic 1 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

39.2 °F - closed cup

flash_point_c

4 °C - closed cup

Regulatory Information

新产品
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Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LC24691V
LC23106V
LC13592
LC13317
LC13139

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. Is Product No. 48599, 2,3,7,8-Tetrachlorodibenzo-p-dioxin solution, appropriate for use in tissue culture studies?

    The 2,3,7,8-Tetrachlorodibenzo-p-dioxin solution (10 μg/mL in toluene), is sold as 1mL in a flame sealed ampule.  It is made to be used as a chemical standard with US EPA drinking and wastewater analytical methods.  We have no knowledge of its use in tissue culture.

  4. Can I get pure 2,3,7,8-Tetrachlorodibenzo-p-dioxin from Sigma-Aldrich?

    No; Sigma-Aldrich has no source for pure 2,3,7,8-Tetrachlorodibenzo-p-dioxin.  It is only available as Supelco 48599: 2,3,7,8-TCDD, 10 μg/mL in toluene, ampule of 1mL.

  5. What is the molecular weight of 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Product 48599?

    The molecular weight of 2,3,7,8-TCDD is 321.97 Da.  

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Karin I van Ede et al.
Toxicology letters, 226(1), 43-52 (2014-01-30)
Human risk assessment for dioxin-like compounds is typically based on the concentration measured in blood serum multiplied by their assigned toxic equivalency factor (TEF). Consequently, the actual value of the TEF is very important for accurate human risk assessment. In
Hongtao Shang et al.
Environment international, 54, 50-58 (2013-02-19)
A total of 60 paired samples of earthworm, corresponding soil and wormcast were collected to investigate the bioaccumulation tendency of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in earthworms from a typical E-waste dismantling area in
Éva Vigh et al.
The Science of the total environment, 449, 336-344 (2013-02-26)
Polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are persistent, bioaccumulative and toxic chemicals. These compounds are transferred to breast milk, therefore breastfed infants are at risk of being exposed to considerable amounts of PCBs and PCDD/Fs during
K A Solak et al.
Toxicology, 311(3), 124-134 (2013-07-23)
The aryl hydrocarbon receptor (AhR) is involved in a wide variety of biological and toxicological responses, including neuroendocrine signaling. Due to the complexity of neuroendocrine pathways in e.g. the hypothalamus and pituitary, there are limited in vitro models available despite
E C Rada et al.
Chemosphere, 110, 53-61 (2014-06-02)
Atmospheric depositions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) were monitored at three sites in the vicinity of a steel making plant, located in an Italian alpine valley. A high variability in the deposition of PCDD/Fs was
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