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Merck
CN

67681

Supelco

N-Nitrosodiisopropylamine

analytical standard

Synonym(s):

N-Isopropyl-N-nitrosoisopropylamine, DIPNA, NDIP

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About This Item

Empirical Formula (Hill Notation):
C6H14N2O
CAS Number:
Molecular Weight:
130.19
MDL number:
UNSPSC Code:
12352116
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grade

analytical standard

Quality Level

Assay

≥99%

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

SMILES string

N(N=O)(C(C)C)C(C)C

InChI

1S/C6H14N2O/c1-5(2)8(7-9)6(3)4/h5-6H,1-4H3

InChI key

AUIKJTGFPFLMFP-UHFFFAOYSA-N

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General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosodiisopropylamine is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

Application

N-Nitrosodiisopropylamine may be used as an analytical reference standard for the determination of several nitrosamines in large volume parenteral (LVP) drug products using liquid chromatography-mass spectrometry (LC/MS/MS).

Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Development and Validation of a Sensitive LC-MS/MS Method for Simultaneous Determination of Several Nitrosamines in Large Volume Parenteral
Jost L, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, qsaf031-qsaf031 (2025)

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