67694
N-Nitroso-N-methyl-4-aminobutyric acid
analytical standard
Synonym(s):
4-(Methylnitrosoamino)butanoic acid, N-Methyl-N-(3-carboxypropyl)nitrosamine
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About This Item
Empirical Formula (Hill Notation):
C5H10N2O3
CAS Number:
Molecular Weight:
146.14
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
grade
analytical standard
Quality Level
assay
≥99%
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
storage temp.
−20°C
General description
Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitroso-N-methyl-4-aminobutyric acid is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.
N-Nitroso-N-methyl-4-aminobutyric acid is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.
Application
N-Nitroso-N-methyl-4-aminobutyric acid may be used as an analytical reference standard for the determination of nitrosamine impurities in sartan drugs using liquid chromatography-mass spectrometry (LC/MS/MS).
Analysis Note
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Warning
hcodes
Hazard Classifications
Carc. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Determination of genotoxic impurity N-Nitroso-N-methyl-4-aminobutyric acid in four Sartan substances through using liquid chromatography-tandem mass spectrometry
Xie B, et al.
Molecules (Basel), 27, 7498-7498 (2022)