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Merck
CN

67694

Supelco

N-Nitroso-N-methyl-4-aminobutyric acid

analytical standard

Synonym(s):

4-(Methylnitrosoamino)butanoic acid, N-Methyl-N-(3-carboxypropyl)nitrosamine

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About This Item

Empirical Formula (Hill Notation):
C5H10N2O3
CAS Number:
61445-55-4
Molecular Weight:
146.14
MDL number:
MFCD00869939
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

100

Assay

≥99%

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

−20°C

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General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitroso-N-methyl-4-aminobutyric acid is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.

Application

N-Nitroso-N-methyl-4-aminobutyric acid may be used as an analytical reference standard for the determination of nitrosamine impurities in sartan drugs using liquid chromatography-mass spectrometry (LC/MS/MS).

Analysis Note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM9919
BCCJ5995

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Determination of genotoxic impurity N-Nitroso-N-methyl-4-aminobutyric acid in four Sartan substances through using liquid chromatography-tandem mass spectrometry
Xie B, et al.
Molecules (Basel), 27, 7498-7498 (2022)

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