68088
N-Nitrosomethylethylamine
analytical standard
Synonym(s):
N-Nitroso-N-methylethylamine, NMEA
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About This Item
Empirical Formula (Hill Notation):
C3H8N2O
CAS Number:
Molecular Weight:
88.11
UNSPSC Code:
12352116
NACRES:
NA.24
MDL number:
grade
analytical standard
Quality Level
assay
≥95%
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
storage temp.
2-8°C
SMILES string
N(N=O)(CC)C
InChI key
RTDCJKARQCRONF-UHFFFAOYSA-N
General description
Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
N-Nitrosomethylethylamine is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.
N-Nitrosomethylethylamine is commonly employed as a reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices.
Application
N-Nitrosomethylethylamine may be used as an analytical reference standard for the quantification of nitrosamine impurities in metformin drug products using liquid chromatography-high resolution mass spectrometry (LC-HRMS).
Analysis Note
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
170.1 °F - closed cup
flash_point_c
76.7 °C - closed cup
Regulatory Information
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A comprehensive approach for N-nitrosamine determination in pharmaceuticals using a novel HILIC-based solid phase extraction and LC-HRMS
Parfant, et al.
Talanta, 282, 126752-126752 (2025)