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About This Item
UNSPSC Code:
41115700
NACRES:
NB.21
Particle size:
75 μm
Matrix active group:
sulphonyl phase
Matrix:
hydroxylated methacrylic polymer
product line
TOYOPEARL®
form
slurry
mol wt
2000 - 1,000,000
feature
counter ion Na+
packaging
bottle of 1 L
manufacturer/tradename
Tosoh 21835
parameter
3 bar max. pressure
technique(s)
LPLC: suitable
matrix
hydroxylated methacrylic polymer
matrix active group
sulphonyl phase
particle size
75 μm
operating pH
3-13
capacity
156 g/L±20 adsorption capacity (hIgG)
separation technique
cation exchange
General description
Toyopearl GigaCap S-650 resin is a high capacity, high resolution cation exchange resin* optimized for process scale applications, including the capture and purification of IgG as well as the polishing of monoclonal antibodies. A Toyopearl HW-65 polymeric bead has been chemically modified to provide a higher number of cationic binding sites for increased resin capacity.
While Toyopearl GigaCap S-650M resin was specifically optimized for IgG, with dynamic binding capacities in the vicinity of 140 mg/mL for IgG, it also exhibits high binding capacities for smaller proteins. Typical dynamic binding capacities for lysozyme are in excess of 160 mg/mL.
Toyopearl GigaCap S-650S resin has dynamic binding capacities approaching 165 g/L for gamma globulin. This high capacity, combined with the 35 μm mean particle size, makes Toyopearl GigaCap S-650S ideal for high resolution applications.
Toyopearl GigaCap S-650 resin is stable at high linear velocities, has good pressure-flow characteristics and will withstand back pressures up to 3 bar. The higher capacity and back pressure stability of Toyopearl GigaCap S-650 resin creates opportunities for increased throughput in downstream cation exchange purification steps.
Toyopearl GigaCap S-650M resin also has excellent base stability in 1.0 mol/L NaOH and shows robust clean in place (CIP) properties with minimal loss of capacity after 50 X 1 hour cycles of caustic exposure also using 1.0 mol/L NaOH. (data)
*specifically designed for packed bed use
While Toyopearl GigaCap S-650M resin was specifically optimized for IgG, with dynamic binding capacities in the vicinity of 140 mg/mL for IgG, it also exhibits high binding capacities for smaller proteins. Typical dynamic binding capacities for lysozyme are in excess of 160 mg/mL.
Toyopearl GigaCap S-650S resin has dynamic binding capacities approaching 165 g/L for gamma globulin. This high capacity, combined with the 35 μm mean particle size, makes Toyopearl GigaCap S-650S ideal for high resolution applications.
Toyopearl GigaCap S-650 resin is stable at high linear velocities, has good pressure-flow characteristics and will withstand back pressures up to 3 bar. The higher capacity and back pressure stability of Toyopearl GigaCap S-650 resin creates opportunities for increased throughput in downstream cation exchange purification steps.
Toyopearl GigaCap S-650M resin also has excellent base stability in 1.0 mol/L NaOH and shows robust clean in place (CIP) properties with minimal loss of capacity after 50 X 1 hour cycles of caustic exposure also using 1.0 mol/L NaOH. (data)
*specifically designed for packed bed use
Features and Benefits
Clean in place with 0.5 M NaOH or 0.1 M HCl.
Physical form
72% (v/v) slurry in 20% (v/v) ethanol
Shipped in 20% (v/v) ethanol.
Legal Information
Toyopearl is a registered trademark of Tosoh Corporation
Toyopearl GigaCap is a registered trademark of Tosoh Corporation
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Flam. Liq. 3
Storage Class
3 - Flammable liquids
WGK
WGK 3
Flash Point (°F)
104.0 °F - closed cup
Flash Point (°C)
40 °C - closed cup
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