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About This Item
Empirical Formula (Hill Notation):
C15H10O5
CAS Number:
Molecular Weight:
270.24
NACRES:
NA.24
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
2059062
MDL number:
grade
primary reference standard
product line
phyproof® Reference Substance
assay
≥95.0% (HPLC)
form
solid
manufacturer/tradename
PhytoLab
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
cannabis testing
format
neat
SMILES string
OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
InChI
1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
InChI key
YDQWDHRMZQUTBA-UHFFFAOYSA-N
General description
Aloe-emodin, an anthraquinone derivative, is an active constituent of several medicinal plants. It shows gastrointestinal effects by exerting laxative activity.
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Application
Aloe-emodin may be used as an analytical reference standard for the determination of the analyte in plant and animal samples by high-performance liquid chromatography technique.
Biochem/physiol Actions
Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.
Other Notes
This compound is commonly found in plants of the genus: aloe
Legal Information
phyproof is a registered trademark of PhytoLab GmbH & Co. KG
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Simultaneous determination and pharmacokinetic studies of aloe emodin and chrysophanol in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography
Tang WF, et al.
Biomedical Chromatography, 21(7), 701-707 (2007)
Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry
ElSohly MA, et al.
International Immunopharmacology, 4(14), 1739-1744 (2004)
One single standard substance for the determination of multiple anthraquinone derivatives in rhubarb using high-performance liquid chromatography-diode array detection
Gao XY, et al.
Journal of Chromatography A, 1216(11), 2118-2123 (2009)