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1012065

USP

Acyclovir

Name: Acyclovir
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):

Acycloguanosine, 9-[(2-Hydroxyethoxy)methyl]guanine, Acyclovir

Empirical Formula (Hill Notation):

C₈H₁₁N₅O₃

CAS Number:

59277-89-3

Molecular Weight:

225.20

MDL number:

MFCD00057880

PubChem Substance ID:

329748935

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

acyclovir

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NC1=Nc2c(ncn2COCCO)C(=O)N1

InChI

1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)

InChI key

MKUXAQIIEYXACX-UHFFFAOYSA-N

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Analytical Reference Standards

Sigma-Aldrich

General description

Acyclovir is a nucleoside analogue antiviral drug. It is a highly potent inhibitor of herpes simplex virus. It is related to cytarabine, idoxuridine, trifluridine and vidarabine.

Application

Acyclovir USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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A0220000

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1012076

Y0001264

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Y0001271

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1012087

1012054

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Acyclovir. A review of its pharmacodynamic properties and therapeutic efficacy.

D M Richards et al.

Drugs, 26(5), 378-438 (1983-11-01)

Acyclovir (aciclovir) is a nucleoside analogue antiviral drug related to cytarabine, idoxuridine, trifluridine and vidarabine. In common with these earlier antivirals, acyclovir is active against some members of the herpesvirus group of DNA viruses. The efficacy of topical acyclovir has

Antimicrobial activities of four Tunisian Chrysanthemum species.

Ahlem Ben Sassi et al.

The Indian journal of medical research, 127(2), 183-192 (2008-04-12)

Tunisian Chrysanthemum species are known to have medicinal activity and some of the species are used in traditional medicine. We have earlier shown the use of C. trifurcatum flowerheads in Tunisian traditional medicine to treat constipation. In the present study

Mechanism of action and selectivity of acyclovir.

G B Elion

The American journal of medicine, 73(1A), 7-13 (1982-07-20)

Acyclovir, an acrylic purine nucleoside analog, is a highly potent inhibitor of herpes simplex virus (HSV), types 1 and 2, and varicella zoster virus, and has extremely low toxicity for the normal host cells. This selectivity is due to the

Derivative spectrophotometric method for determination of acyclovir in polymeric nanoparticles.

Tavares, Guilherme Diniz, et al.

Quimica nova, 35.1, 203-206 (2012)

Is prophylactic acyclovir treatment warranted for prevention of herpes simplex virus infections in facial burns? A review of the literature.

Josef Haik et al.

Journal of burn care & research : official publication of the American Burn Association, 32(3), 358-362 (2011-03-24)

Both cosmetic facial resurfacing and facial burns cause an injury to the dermal layer of the skin. This injury renders the patient susceptible to primary herpes simplex virus (HSV) infection or, more commonly, to HSV reactivation. This in turn can

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