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Merck
CN

1012917

USP

Alfuzosin hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide hydrochloride, Uroxatral hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H27N5O4 · HCl
CAS Number:
81403-68-1
Molecular Weight:
425.91
NACRES:
NA.24
PubChem Substance ID:
329748956
UNSPSC Code:
41116107
MDL number:
MFCD00879135

Key Documents

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Product Name

Alfuzosin hydrochloride, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H

SMILES string

Cl.COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3

InChI key

YTNKWDJILNVLGX-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

alfuzosin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Alfuzosin hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Alfuzosin Hydrochloride Extended-Release Tablets

Biochem/physiol Actions

Alfuzosin hydrochloride is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
Alfuzosin hydrochloride is an alpha-adrenergic blocker.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Jarosław Szulfer et al.
Journal of chromatography. A, 1346, 69-77 (2014-05-06)
This paper focuses on the application of a column classification system based on the Katholieke Universiteit Leuven for the characterization of physicochemical properties of core-shell and ultra-high performance liquid chromatographic stationary phases, followed by the verification of the reliability of

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