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Merck
CN

1018505

USP

Amantadine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.13,7]decan-1-amine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C10H17N · HCl
CAS Number:
665-66-7
Molecular Weight:
187.71
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329748968
MDL number:
MFCD00074723
Beilstein/REAXYS Number:
4198854

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InChI

1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;

SMILES string

Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3

InChI key

WOLHOYHSEKDWQH-SOVZANNPSA-N

grade

pharmaceutical primary standard

API family

amantadine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amantadine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amantadine Hydrochloride Tablets
  • Amantadine Hydrochloride Capsules
  • Amantadine Hydrochloride Oral Solution
  • Memantine Hydrochloride Tablets

Biochem/physiol Actions

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Corr. 1B

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Certificates of Analysis (COA)

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Anti-SARS-CoV-2 Activity of Adamantanes In Vitro and in Animal Models of Infection.
Lim, et al.
COVID, 2, 1551-1563 (2023)

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