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Merck
CN

1045009

USP

Atropine sulfate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Atropine sulfate salt monohydrate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, Tropine tropate

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About This Item

Linear Formula:
(C17H23NO3)2 · H2SO4 · H2O
CAS Number:
5908-99-6
Molecular Weight:
694.83
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329749082
MDL number:
MFCD00074815
Beilstein/REAXYS Number:
6109275

Key Documents

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Product Name

Atropine sulfate, United States Pharmacopeia (USP) Reference Standard

SMILES string

O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6

InChI key

JPKKQJKQTPNWTR-CHYDPLAESA-N

InChI

1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;

grade

pharmaceutical primary standard

API family

atropine

manufacturer/tradename

USP

mp

189-192 °C (A) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Atropine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Atropine Sulfate Injection
  • Atropine Sulfate Ophthalmic Solution
  • Atropine Sulfate Ophthalmic Ointment
  • Diphenoxylate Hydrochloride and Atropine Sulfate Tablets
  • Diphenoxylate Hydrochloride and Atropine Sulfate Oral Solution
  • Atropine

Biochem/physiol Actions

Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

Regulatory Information

涉药品监管产品
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