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Merck
CN

1065210

USP

Berberine chloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Berberine chloride form, Natural Yellow 18

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About This Item

Empirical Formula (Hill Notation):
C20H18ClNO4
CAS Number:
633-65-8
Molecular Weight:
371.81
PubChem Substance ID:
329748923
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00011939
Colour Index Number:
75160
Beilstein/REAXYS Number:
3836585

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Product Name

Berberine chloride, United States Pharmacopeia (USP) Reference Standard

SMILES string

COC1=C(C=[N+](CCC2=C3C=C4C(OCO4)=C2)C3=C5)C5=CC=C1OC.[Cl-]

InChI key

VKJGBAJNNALVAV-UHFFFAOYSA-M

InChI

1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1

grade

pharmaceutical primary standard

API family

berberine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Berberine chloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Coptis Species Rhizome
  • Coptis Species Rhizome Dry Extract
  • Coptis Species Rhizome Powder
  • Goldenseal
  • Indian Barberry Stem
  • Indian Barberry Stem Dry Extract
  • Indian Barberry Stem Powder
Fluorescent stain for heparin in mast cells

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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