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Merck
CN

1075757

USP

Bisoprolol fumarate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Bisoprolol hemifumarate salt, 1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate salt

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About This Item

Empirical Formula (Hill Notation):
C18H31NO4 · .5C4H4O4
CAS Number:
104344-23-2
Molecular Weight:
383.48
NACRES:
NA.24
PubChem Substance ID:
329749125
UNSPSC Code:
41116107
MDL number:
MFCD00792743

Key Documents

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InChI

1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+

SMILES string

OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1.CC(C)NCC(O)COc2ccc(COCCOC(C)C)cc2

InChI key

VMDFASMUILANOL-WXXKFALUSA-N

grade

pharmaceutical primary standard

API family

bisoprolol

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ADRB1(153)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Cardioselective β1-adrenoceptor antagonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - STOT RE 2

target_organs

Heart

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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Bisoprolol Fumarate Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(5) (2013)
Bisoprolol Fumarate and Hydrochlorothiazide Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(2) (2013)
Naseem A Charoo et al.
Journal of pharmaceutical sciences, 103(2), 378-391 (2014-01-03)
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing bisoprolol as the sole active pharmaceutical ingredient (API) are reviewed. Bisoprolol is classified
Roman Gähwiler et al.
Praxis, 103(9), 527-531 (2014-04-24)
We report the case of a 38-year patient who presented in our outpatient clinic for cardiac evaluation and assessment as volunteer firefighter. The patient had an asymptomatic sinustachycardia, which was diagnosed at the age of 15. After we excluded secondary
In reply.
Catherine Ashes et al.
Anesthesiology, 120(5), 1287-1288 (2014-04-24)
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