Skip to Content
Merck
CN

1082300

USP

Butoconazole nitrate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole mononitrate

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C19H17Cl3N2S · HNO3
CAS Number:
64872-77-1
Molecular Weight:
474.79
NACRES:
NA.24
PubChem Substance ID:
329749174
UNSPSC Code:
41116107
MDL number:
MFCD00058159

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Butoconazole nitrate, United States Pharmacopeia (USP) Reference Standard

InChI key

ZHPWRQIPPNZNML-UHFFFAOYSA-N

SMILES string

ClC1=C(C(Cl)=CC=C1)SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3.O[N+]([O-])=O

InChI

1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)

grade

pharmaceutical primary standard

API family

butoconazole

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Looking for similar products? Visit Product Comparison Guide

Related Categories

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Butoconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monograph such as Butoconazole Nitrate Vaginal Cream.

General description

Butoconazole nitrate (BN) is a imidazole used as an antifungal agent.

Other Notes

Sales restrictions may apply.

Hazard Classifications

Acute Tox. 4 Oral

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Meng-meng Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 34(3), 431-436 (2014-06-19)
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of butoconazole in human plasma. Human plasma samples of 0.2 μL were pretreated by a single step protein precipitation procedure and analyzed using a high performance
J B Jacobson et al.
Acta obstetricia et gynecologica Scandinavica, 64(3), 241-244 (1985-01-01)
The continuously increasing incidence of vulvovaginal candidiasis necessitated a search for novel therapeutic modalities. Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate
[Butoconazole nitrate in vulvovaginal candidiasis. A comparative study with clotrimazole].
E Herrera Nava et al.
Ginecologia y obstetricia de Mexico, 56, 138-143 (1988-05-01)
A J Hajman
The Journal of international medical research, 16(5), 367-375 (1988-09-01)
Sixty-three women with laboratory confirmed diagnoses of vulvovaginal candidosis were enrolled into this randomized, single-blind, parallel comparison of treatment with 2% butoconazole nitrate cream for 3 days and 1% clotrimazole cream for 6 days. Approximately 1 week after treatment ended
Sebastian Hahnel et al.
Journal of materials science. Materials in medicine, 20(1), 249-255 (2008-09-02)
The aim of this in vitro study was to examine potential changes and influences of prosthetic resin surface properties on Candida albicans adhesion after surface treatment or artificial ageing. Standardized specimens of a denture base resin and a veneering composite
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service