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Merck
CN

1118350

USP

Chloroquine Related Compound D

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline, Monodesethylchloroqu​ine

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About This Item

Empirical Formula (Hill Notation):
C16H22ClN3
CAS Number:
1476-52-4
Molecular Weight:
291.82
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00871808

Key Documents

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Product Name

Chloroquine Related Compound D, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)

SMILES string

ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2

InChI key

MCYUUUTUAAGOOT-UHFFFAOYSA-N

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

API family

chloroquine

form

powder

packaging

pkg of 15 mg

manufacturer/tradename

USP

storage condition

protect from light

color

tan

bp

343.4-347 °F (173—175°C; 845.06°F )

mp

176-215.6 °F (80—102°C)

solubility

chloroform: soluble
dichloromethane: soluble

density

1.14 g/cm3

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Chloroquine Related Compound D USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Chloroquine Phosphate

General description

Chloroquine Related Compound D is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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HPLC with ultraviolet detection for the determination of chloroquine and desethylchloroquine in whole blood and finger-prick capillary blood dried on filter paper
Cheomung A and Na-Bangchang K
Journal of Pharmaceutical and Biomedical Analysis, 55(5), 1031-1040 (2011)
An HPLC method with diode array detector for the simultaneous quantification of chloroquine and desethylchloroquine in plasma and whole blood samples from Plasmodium vivax patients in Vietnam, using quinine as an internal standard
Van Pham T, et al.
Biomedical Chromatography, 30(7), 1104-1111 (2016)
Chloroquine Phosphate USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
Vincent MJ, et al.
Virology Journal, 2(1), 1-10 (2005)

Protocols

Chloroquine Phosphate HPLC Assay & Impurity Profiling

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

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