USP

Citric acid

Name: Citric acid
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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About This Item

Linear Formula:

HOC(COOH)(CH₂COOH)₂

CAS Number:

77-92-9

Molecular Weight:

192.12

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329749410

MDL number:

MFCD00011669

Beilstein/REAXYS Number:

782061

Key Documents

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Product Name

Citric acid, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

citric acid

form

crystalline

expl. lim.

8 %, 65 °F

manufacturer/tradename

USP

pKa

(1) 3.13, (2) 4.76, (3) 6.4

mp

153-159 °C (lit.)

solubility

water: 383 g/L at 25 °C

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

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Related Categories

Analytical Reference Materials for Pharma QC

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Application

Citric acid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Anhydrous Citric Acid
Citric Acid Monohydrate
Magnesium Carbonate, Citric Acid, and Potassium Citrate for Oral Solution
Monoglyceride Citrate
Powdered Garcinia Hydroxycitrate Extract
Anticoagulant Citrate Phosphate Dextrose Solution
Potassium Citrate Extended-Release Tablets

General description

Citric acid is a weak organic acid naturally found in citrus fruits. It is widely used as an acidulant, preservative, and flavoring agent in the food and pharmaceutical industries. In pharmaceutical formulations, citric acid acts as a buffering agent to control pH and enhance the stability of active ingredients. The USP Citric Acid standard ensures the consistency and quality of citric acid used in these applications.The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Other Notes

Sales restrictions may apply.

This product is part of USP Biologics Program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

pictograms

GHS07

signalword

Warning

hcodes

H319,H335

pcodes

P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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