1147009
USP
Colistimethate sodium
United States Pharmacopeia (USP) Reference Standard
Synonym(s):
Colistin sulphomethate sodium
grade
pharmaceutical primary standard
API family
colistimethate
form
solid
manufacturer/tradename
USP
application(s)
USP Biologics
pharmaceutical (small molecule)
format
neat
storage temp.
−20°C
SMILES string
[Na+].[Na+].[Na+].[Na+].[Na+].[S](=O)(=O)([O-])CNCCC1NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(CCNC(=O)C(NC1=O)C(O)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CCCCC(CC)C)CCNC[S](=O)(=O)[O-])C(O)C)CCNC[S](=O)(=O)[O-])CCNC[S](=O)(=O)[O-])CC(C)C)CC(C)C)CCNC[S](=O)(=O)[O-]
InChI
1S/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5
InChI key
IQWHCHZFYPIVRV-UHFFFAOYSA-I
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General description
Colistimethate sodium is a prodrug of colistin, designed to reduce toxicity and improve solubility. It exhibits activity against Gram-negative bacteria by disrupting membrane integrity. The USP reference standard supports microbiological assay and identity verification protocols.
The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.
The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.
Application
Analysis Note
Other Notes
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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