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Merck
CN

1152030

USP

Ibu Dg Beta-Cyanoethyl Phosphoramidite

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(5′-O-Dimethoxytrityl-N2 -isobutyryl-2′-deoxyguanosine-3′-O-(2-cyanoethyl-N,Ndiisopropyl)phosphoramidite)

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About This Item

Empirical Formula (Hill Notation):
C44H54N7O8P
CAS Number:
93183-15-4
Molecular Weight:
839.92
MDL number:
MFCD00055147
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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InChI key

FDRMKYVTIFSDPR-MMROLVBFSA-N

InChI

1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,4

SMILES string

P(N(C(C)C)C(C)C)(O[C@@H]1[C@H](O[C@H](C1)[n]5c6nc([nH][c](c6nc5)=O)NC(=O)C(C)C)COC(c4ccc(cc4)OC)(c3ccc(cc3)OC)c2ccccc2)OCCC#N

grade

pharmaceutical primary standard

agency

USP

form

powder

manufacturer/tradename

USP

application(s)

USP Biologics
pharmaceutical

format

neat

storage temp.

−20°C

Related Categories

General description

This reagent is an isobutyryl-protected deoxyguanosine phosphoramidite, used for the incorporation of deoxyguanosine residues into synthetic DNA strands.

The USP biologics oligonucleotides category includes a variety of synthetic nucleic acid sequences that are essential in research, diagnostics, and therapeutic applications. These oligonucleotides play crucial roles in molecular biology, including gene expression regulation, antisense therapy, and RNA interference. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of oligonucleotide products throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.
This product is part of USP Biologics Program.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
USP issued SDS can be found here

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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