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Merck
CN

1249406

USP

Escitalopram oxalate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

S-(+)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate, S-(+)-Citalopram oxalate

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About This Item

Empirical Formula (Hill Notation):
C20H21FN2O · C2H2O4
CAS Number:
219861-08-2
Molecular Weight:
414.43
NACRES:
NA.24
PubChem Substance ID:
329749746
UNSPSC Code:
41116107
MDL number:
MFCD06407826

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InChI

1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1

SMILES string

OC(=O)C(O)=O.CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI key

KTGRHKOEFSJQNS-BDQAORGHSA-N

grade

pharmaceutical primary standard

Gene Information

human ... SLC6A4(6532)

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Escitalopram oxalate, the S-enantiomer of racemic citalopram, belongs to the class of compounds known as antidepressants, that works as a selective serotonin-reuptake inhibitor (SSRI).

Application

Escitalopram oxalate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Escitalopram Oral Solution
  • Escitalopram Oxalate
  • Escitalopram Tablets

Biochem/physiol Actions

Escitalopram is a selective serotonin reuptake inhibitor (SSRI), the S-enantiomer and eutomer of citalopram.
Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI); the S-enantiomer and eutomer of citalopram.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Spectrophotometric and reversed-phase high-performance liquid chromatographic methods for simultaneous determination of escitalopram oxalate and clonazepam in combined tablet dosage form
Gandhi VS, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 91(1), 33-38 (2008)
Application Of Stability Indicating Hptlc Method For Quantitative Determination Of Escitalopram Oxalate In Pharmaceutical Dosage Form.
Mahadik VM, et al.
Eurasian Journal of Analytical Chemistry, 2(2) (2007)
Dietmar Hestermann et al.
Behavioural brain research, 273, 155-165 (2014-07-22)
Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has
Simultaneous HPTLC determination of escitalopram oxalate and clonazepam in combined tablets.
Dhavale N, et al.
Chromatographia, 67(5-6), 487-490 (2008)
Kristan A Leech et al.
Journal of neurotrauma, 31(15), 1334-1342 (2014-04-20)
Incomplete spinal cord injury (iSCI) often results in significant motor impairments that lead to decreased functional mobility. Loss of descending serotonergic (5HT) input to spinal circuits is thought to contribute to motor impairments, with enhanced motor function demonstrated through augmentation
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