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1269200

USP

Famotidine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Famotidine, N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine

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About This Item

Empirical Formula (Hill Notation):
C8H15N7O2S3
CAS Number:
76824-35-6
Molecular Weight:
337.45
NACRES:
NA.24
PubChem Substance ID:
329749830
UNSPSC Code:
41116107
MDL number:
MFCD00079297
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biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

famotidine

form

powder

packaging

pkg of 125 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white to pale yellow-white

mp

325.4-327.2 °F (163—164°C)

solubility

DMF: freely soluble, acetone: practically insoluble, chloroform: practically insoluble, ethanol: practically insoluble, ether: practically insoluble, ethyl acetate: practically insoluble, glacial acetic acid: freely soluble, methanol: slightly soluble, water: very slightly soluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

Gene Information

human ... HRH2(3274)

General description

Famotidine is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Famotidine can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.(10)

Biochem/physiol Actions

H2 histamine receptor antagonist; anti-ulcer agent

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Simultaneous determination of famotidine and flurbiprofen by high performance liquid chromatography
Hanif M, et al.
Tropical Journal of Pharmaceutical Research, 15(3), 605-611 (2016)
Determination of cimetidine, famotidine, and ranitidine hydrochloride in the presence of their sulfoxide derivatives in pure and dosage forms by high-performance thin-layer chromatography and scanning densitometry
Kelani KM, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 85(5), 1015-1020 (2002)
Famotidine
Pharmacopeia, US
United States Pharmacopeia, 39(1)(1-2), 1815-1815 (2020)
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Global Trade Item Number

SKUGTIN
1269200-125MG04061838724533