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1317007

USP

Hydrocortisone acetate

Name: Hydrocortisone acetate
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Hydrocortisone 21-acetate, 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-acetate, 17-α-Hydroxycorticosterone acetate, 17-Hydroxycorticosterone 21-acetate, 21-Acetoxy-4-pregnene-11β,17α-diol-3,20-dione, 4-Pregnene-11β,17α,21-triol-3,20-dione 21-acetate

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₂O₆

CAS Number:

50-03-3

Molecular Weight:

404.50

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329750076

MDL number:

MFCD00037714

Beilstein/REAXYS Number:

2066841

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grade

pharmaceutical primary standard

API family

hydrocortisone

manufacturer/tradename

USP

mp

223 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

Gene Information

human ... NR3C1(2908)

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Related Categories

Analytical Reference Materials for Pharma QC

Pharmacopeia & Metrological Institute Standards

Reference Materials

Analytical Chemistry

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone acetate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

Hydrocortisone Acetate Cream
Hydrocortisone Acetate Lotion
Hydrocortisone Acetate Ointment
Neomycin Sulfate and Hydrocortisone Acetate Ointment
Neomycin Sulfate and Hydrocortisone Acetate Ophthalmic Suspension
Oxytetracycline Hydrochloride and Hydrocortisone Acetate Ophthalmic Suspension
Neomycin and Polymyxin B Sulfates and Hydrocortisone Acetate Cream

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

pictograms

GHS08

signalword

Danger

hcodes

H360Df,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

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Control of transdermal permeation of hydrocortisone acetate from hydrophilic and lipophilic formulations.

Adamo Fini et al.

AAPS PharmSciTech, 9(3), 762-768 (2008-06-20)

The purpose of this research was the preparation of four formulations containing hydrocortisone acetate (HCA) for topical application, including two aqueous systems (hydrophilic microemulsion and aqueous gel) and two systems with dominant hydrophobicity (hydrophobic microemulsion and ointment). The formulations were

An integrated in vitro imaging platform for characterizing filarial parasite behavior within a multicellular microenvironment.

Timothy Kassis et al.

PLoS neglected tropical diseases, 8(11), e3305-e3305 (2014-11-21)

Lymphatic Filariasis, a Neglected Tropical Disease, is caused by thread-like parasitic worms, including B. malayi, which migrate to the human lymphatic system following transmission. The parasites reside in collecting lymphatic vessels and lymph nodes for years, often resulting in lymphedema

Janyce A Sugui et al.

Journal of clinical microbiology, 52(10), 3707-3721 (2014-08-08)

Aspergillus section Fumigati contains 12 clinically relevant species. Among these Aspergillus species, A. fumigatus is the most frequent agent of invasive aspergillosis, followed by A. lentulus and A. viridinutans. Genealogical concordance and mating experiments were performed to examine the relationship

GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin.

Dan-Ni Wang et al.

Medical mycology, 52(5), 506-518 (2014-05-23)

Gliotoxin is an important virulence factor of Aspergillus fumigatus. Although GliA putatively belongs to the major facilitator superfamily in the gliotoxin biosynthesis cluster, its roles remain unclear. To determine the function of GliA, we disrupted gliA in A. fumigatus. gliA

Global Trade Item Number

SKU	GTIN
1317007-200MG	04061838728531

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