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1362103

USP

Levofloxacin

Name: Levofloxacin
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):

Levofloxacin hemihydrate

Empirical Formula (Hill Notation):

C₁₈H₂₀FN₃O₄ · 0.5H₂O

CAS Number:

138199-71-0

Molecular Weight:

370.38

MDL number:

MFCD07772024

PubChem Substance ID:

329750045

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

levofloxacin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O.C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc4C(=O)C(=CN1c24)C(O)=O.C[C@H]5COc6c(N7CCN(C)CC7)c(F)cc8C(=O)C(=CN5c68)C(O)=O

InChI

1S/2C18H20FN3O4.H2O/c2*1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21;/h2*7-8,10H,3-6,9H2,1-2H3,(H,24,25);1H2/t2*10-;/m00./s1

InChI key

SUIQUYDRLGGZOL-RCWTXCDDSA-N

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Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

Application

Levofloxacin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1362114

1362125

1362136

1362169

1362158

PHR2229

PHR2230

Pictograms

GHS07,GHS08

Signal Word

Danger

Hazard Statements

H302 - H317 - H334

Precautionary Statements

P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy.

R Davis et al.

Drugs, 47(4), 677-700 (1994-04-01)

Levofloxacin, an oral fluoroquinolone antibacterial agent, is the optical S-(-) isomer of ofloxacin. In vitro it is generally twice as potent as ofloxacin. Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate activity against anaerobes. Drug

Analysis and Standardization of Levofloxacin Substance.

Sedova, M. K., et al.

Pharmaceutical Chemistry Journal, 47.11, 620-626 (2014)

Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors.

Sabine Schuster et al.

Antimicrobial agents and chemotherapy, 58(11), 6870-6878 (2014-09-04)

Efflux is an important mechanism of bacterial multidrug resistance (MDR), and the inhibition of MDR pumps by efflux pump inhibitors (EPIs) could be a promising strategy to overcome MDR. 1-(1-Naphthylmethyl)-piperazine (NMP) and phenylalanine-arginine-β-naphthylamide (PAβN) are model EPIs with activity in

Once-daily, oral levofloxacin monotherapy for low-risk neutropenic fever in cancer patients: a pilot study in China.

Lixian He et al.

Anti-cancer drugs, 26(3), 359-362 (2014-12-09)

This pilot study assesses the safety and efficacy of once-daily, oral levofloxacin monotherapy in Chinese patients with low-risk febrile neutropenia. In this prospective, single-arm, open-label, multicenter clinical trial, 46 adult Chinese patients with solid tumors and low-risk febrile neutropenia were

Evaluation of dry eye and meibomian gland dysfunction after cataract surgery.

Kyung Eun Han et al.

American journal of ophthalmology, 157(6), 1144-1150 (2014-02-25)

To evaluate dry eye and meibomian gland dysfunction after cataract surgery. Prospective observational case series. We studied 58 eyes of 48 patients who underwent phacoemulsification and evaluated them preoperatively and at 1 month and 3 months postoperatively. Ocular symptom scores

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