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1370101

USP

Lopinavir

Name: Lopinavir
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):

C₃₇H₄₈N₄O₅

CAS Number:

192725-17-0

Molecular Weight:

628.80

MDL number:

MFCD22628840

UNSPSC Code:

41116107

NACRES:

NA.24

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biological source

synthetic

grade

pharmaceutical primary standard

agency

USP/NF

API family

lopinavir

form

powder

packaging

pkg of 350 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white to off-white

mp

255.2-260.6 °F (124—127°C)

solubility

chloroform: soluble, isopropanol: soluble, methanol: freely soluble, methylene chloride: freely soluble, water: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N4(CCCNC4=O)[C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@@H](NC(=O)COc3c(cccc3C)C)Cc2ccccc2)Cc1ccccc1

InChI

1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

InChI key

KJHKTHWMRKYKJE-SUGCFTRWSA-N

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Related Categories

Analytical Reference Materials for Pharma QC

Pharmacopeia & Metrological Institute Standards

General description

Lopinavir is an antiretroviral agent and a protease inhibitor indicated for the management of human immunodeficiency virus (HIV) infection. It is a key component of Kaletra, the co-formulation of lopinavir and ritonavir.

Application

Lopinavir may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography techniques.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lopinavir USP Monograph

USP43-NF38: United States Pharmacopeia and National Formulary

United States Pharmacopeia, 37(6), 2610-2610 (2020)

Determination of 19 antiretroviral agents in pharmaceuticals or suspected products with two methods using high-performance liquid chromatography

Rebiere H, et al.

Journal of Chromatography. B, Biomedical Applications, 850(1-2), 376-383 (2007)

Simultaneous determination of indinavir, ritonavir and lopinavir (ABT 378) in human plasma by high-performance liquid chromatography

Ray J, et al.

Journal of Chromatography. B, Biomedical Applications, 775(2), 225-230 (2002)

Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy

Lambert JS, et al.

HIV Medicine, 12(3), 166-173 (2011)

Validation and application of a high-performance liquid chromatography-tandem mass spectrometric method for simultaneous quantification of lopinavir and ritonavir in human plasma using semi-automated 96-well liquid-liquid extraction

Wang PG, et al.

Journal of Chromatography A, 1130(2), 302-307 (2006)

Global Trade Item Number

SKU	GTIN
1370101-350MG	04061833845196

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