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1370462

USP

Losartan potassium

Name: Losartan potassium
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):

2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt, DuP 753, MK 954, Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide

Empirical Formula (Hill Notation):

C₂₂H₂₂ClKN₆O

CAS Number:

124750-99-8

Molecular Weight:

461.00

Beilstein:

5845770

MDL number:

MFCD02092704

PubChem Substance ID:

329750264

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

losartan

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]

InChI

1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChI key

OXCMYAYHXIHQOA-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

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Analytical Reference Standards

Sigma-Aldrich

General description

Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.

Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension.

Application

Losartan potassium was used as reference standard for determination of Losartan and metabolite in rat urine samples using HPLC coupled with fluorescence detector.

Biochem/physiol Actions

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1370473

1370495

1370484

1370509

1370510

BP867

Losartan potassium, British Pharmacopoeia (BP) Reference Standard

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells.

D M Dorfman et al.

The Journal of biological chemistry, 267(2), 1279-1285 (1992-01-15)

Previously, we showed that the promoter of the gene encoding preproendothelin-1 (PPET-1) contains a GATA motif that is essential for activity and interacts with a nuclear factor similar in size and binding specificity to the erythroid transcription factor GATA-1. To

Quantification of losartan and its metabolite in rat urine

Prolina, OG, et al.

Bulletin of Moscow University, 53.3, 194-197 (2012)

Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK.

Jill Wylie-Sears et al.

Biochemical and biophysical research communications, 446(4), 870-875 (2014-03-19)

Adult cardiac valve endothelial cells (VEC) undergo endothelial to mesenchymal transformation (EndMT) in response to transforming growth factor-β (TGFβ). EndMT has been proposed as a mechanism to replenish interstitial cells that reside within the leaflets and further, as an adaptive

Angiotensin II mobilizes intracellular calcium and activates pannexin-1 channels in rat carotid body type II cells via AT1 receptors.

Sindhubarathi Murali et al.

The Journal of physiology, 592(21), 4747-4762 (2014-08-31)

Clinical pharmacology of the angiotensin II receptor antagonist losartan potassium in healthy subjects.

M Burnier et al.

Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 13(1), S23-S28 (1995-07-01)

The evaluation of a new drug in normotensive volunteers provides important pharmacodynamic and pharmacokinetic information as long as the compound has a specific mechanism of action which can be evaluated in healthy subjects as well as in patients. The purpose

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