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Merck
CN

1426002

USP

Methyldopa

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Methyl-DOPA sesquihydrate, 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine, MK-351, Methyl-L-DOPA

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About This Item

Empirical Formula (Hill Notation):
C10H13NO4 · 1.5H2O
CAS Number:
41372-08-1
Molecular Weight:
238.24
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329750434
MDL number:
MFCD00004186
Beilstein/REAXYS Number:
2417244

Key Documents

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Product Name

Methyldopa, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1

SMILES string

C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O

InChI key

CJCSPKMFHVPWAR-JTQLQIEISA-N

grade

pharmaceutical primary standard

API family

methyldopa

manufacturer/tradename

USP

mp

≥300 °C

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Methyldopa USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Qi Chang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 805(2), 275-280 (2004-05-12)
A new method for the determination of tranexamic acid (TA) in human plasma using high performance liquid chromatography with tandem mass spectrometric detection was described. TA and the internal standard, methyldopa, was extracted from a 200 l plasma sample by
P A van Zwieten et al.
Hypertension (Dallas, Tex. : 1979), 6(5 Pt 2), II28-II33 (1984-09-01)
Clonidine (Catapres, Catapresan), guanfacine (Estulic), and methyldopa (Aldomet) are the prototypes of centrally acting antihypertensive drugs. Clonidine and guanfacine are lipophilic drugs that readily penetrate into the brain, where they stimulate alpha-adrenergic receptors in the pontomedullary region. The stimulation of
Li-Ting Liao et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 72-77 (2014-05-13)
Uric acid measurement has become increasingly important, and electrochemically modified detection method based portable devices hold a dominant position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a lack of

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