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Merck
CN

1463304

USP

Nicotine bitartrate dihydrate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(−)-Nicotine hydrogen tartrate salt dihydrate

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About This Item

Empirical Formula (Hill Notation):
C10H14N2 · 2C4H6O6 · 2H2O
CAS Number:
6019-06-3
Molecular Weight:
498.44
MDL number:
MFCD00150899
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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SMILES string

Clc1cc2c(cc1)O\C(=C3\C=C(C=CC\3=O)NC(=O)C(C)C)\N2

InChI

1S/C17H15ClN2O3/c1-9(2)16(22)19-11-4-5-14(21)12(8-11)17-20-13-7-10(18)3-6-15(13)23-17/h3-9,20H,1-2H3,(H,19,22)/b17-12-

InChI key

YGMGVHYZWYRTJJ-ATVHPVEESA-N

grade

pharmaceutical primary standard

API family

nicotine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nicotine bitartrate dihydrate USP reference standard for use in specified quality tests and assays.

Also used to prepare standard, system suitability, sensitivity, and standard stock solution for assay, identification, performance test, and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
  • Nicotine
  • Nicotine Polacrilex
  • Nicotine Transdermal System

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT RE 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Nicotine Transdermal System
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 3153-3153 (2021)
Nicotine
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(5) (2022)
Cheng Xiao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 3734-3746 (2015-03-06)
The glutamatergic subthalamic nucleus (STN) exerts control over motor output through nuclei of the basal ganglia. High-frequency electrical stimuli in the STN effectively alleviate motor symptoms in movement disorders, and cholinergic stimulation boosts this effect. To gain knowledge about the
Nicotine Polacrilex
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(1), 3156-3156 (2020)
Brandon J Henderson et al.
The Journal of general physiology, 143(1), 51-66 (2014-01-01)
Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson's disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in

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