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Merck
CN

1482207

USP

Oxaprozin

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

4,5-Diphenyl-2-oxazolepropanoic acid, Daypro

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About This Item

Empirical Formula (Hill Notation):
C18H15NO3
CAS Number:
21256-18-8
Molecular Weight:
293.32
NACRES:
NA.24
PubChem Substance ID:
329750632
UNSPSC Code:
41116107
MDL number:
MFCD00215977

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Product Name

Oxaprozin, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)

SMILES string

OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3

InChI key

OFPXSFXSNFPTHF-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

oxaprozin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Oxaprozin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Oxaprozin Tablets

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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M A al-Faks et al.
Orthopaedic review, 21(5), 558-558 (1992-05-01)
Oxaprozin, a propionic acid derivative, is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its spectrum of anti-inflammatory activity has been demonstrated in both in vitro and in vivo models.1 The majority of published clinical trials have focused
L G Miller
Clinical pharmacy, 11(7), 591-603 (1992-07-01)
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of oxaprozin are reviewed. Oxaprozin, a nonsteroidal anti-inflammatory drug (NSAID) under consideration for approval by the Food and Drug Administration, is characterized as a propionic acid. By inhibiting cyclo-oxygenase, oxaprozin decreases
P A Todd et al.
Drugs, 32(4), 291-312 (1986-10-01)
Oxaprozin is a newer non-steroidal anti-inflammatory drug advocated for use in painful rheumatic and inflammatory conditions. As is the case with some other newer non-steroidal anti-inflammatory drugs, oxaprozin offers the convenience of once-daily administration. Published data suggest that oxaprozin 1200
N M Davies
Clinical pharmacokinetics, 35(6), 425-436 (1999-01-13)
Oxaprozin is a nonsteroidal anti-inflammatory drug which reaches peak plasma concentrations 2 to 6 hours after oral administration. Oxaprozin binds extensively, in a concentration-dependent manner, to plasma albumin. The area under the plasma concentration-time curve (AUC) of oxaprozin is linearly
Franco Dallegri et al.
Expert opinion on pharmacotherapy, 6(5), 777-785 (2005-06-07)
Oxaprozin is a nonsteroidal anti-inflammatory drug characterised by a propionic acid-based structure. It is able to diffuse easily into inflamed synovial tissues after oral administration. Although discovered > 20 years ago, it is now under intensive investigation because of its
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