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1500218

USP

Paroxetine hydrochloride

Name: Paroxetine hydrochloride
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):

Paroxetine hydrochloride hemihydrate, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

Empirical Formula (Hill Notation):

C₁₉H₂₀FNO₃ · HCl · .5 H₂O

CAS Number:

110429-35-1

Molecular Weight:

374.83

MDL number:

MFCD03658863

PubChem Substance ID:

329750674

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

paroxetine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1

InChI key

QRQSGFFISBKLMZ-YHOFXEKLSA-N

Gene Information

human ... SLC6A4(6532)

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

Paroxetine hydrochloride is a phenylpiperidine derivative which is selective serotonin reuptake inhibitor. The protein binding ability is high. It has 2 forms, non-hygroscopic hemihydrate and hygroscopic anhydrate. This drug is seen useful in treating premature ejaculation in men.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Paroxetine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1500230

1500240

1500251

1500273

1500284

Y0000579

Paroxetine hydrochloride (anhydrous) impurity C, European Pharmacopoeia (EP) Reference Standard

BP1024

Paroxetine hydrochloride hemihydrate, British Pharmacopoeia (BP) Reference Standard

BP746

Paroxetine impurity standard, British Pharmacopoeia (BP) Reference Standard

1500207

PHR3076

PHR3077

Pictograms

GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302 - H317 - H319 - H335 - H410

Precautionary Statements

P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Perinatal outcome following third trimester exposure to paroxetine.

Costei, Adriana Moldovan, et al.

Archives of Pediatrics & Adolescent Medicine, 156.11, 1129-1132 (2002)

Treatment of premature ejaculation with paroxetine hydrochloride.

C G McMahon et al.

International journal of impotence research, 11(5), 241-245 (1999-12-20)

To evaluate the efficacy of chronic and 'on demand' administration of paroxetine hydrochloride in the drug treatment of premature ejaculation (PE). Ninety-four normally potent men, aged 18-61 y (mean 39 y) with premature ejaculation were treated between January 1996 and

Solid-state forms of paroxetine hydrochloride.

Buxton, P. Christopher, Ian R. Lynch, and John M. Roe.

International Journal of Pharmaceutics, 42.1, 135-143 (1988)

Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study.

E Di Girolamo et al.

Journal of the American College of Cardiology, 33(5), 1227-1230 (1999-04-08)

The purpose of the study was to determine whether the well tolerated serotonin reuptake inhibitor paroxetine hydrochloride could prevent vasovagal syncope in patients resistant to or intolerant of previous traditional therapies. Serotonergic mechanisms play a major role in the processes

A new SiF-Dipropargyl glycerol scaffold as a versatile prosthetic group to design dimeric radioligands: synthesis of the [(18) F]BMPPSiF tracer to image serotonin receptors.

Puja Panwar Hazari et al.

ChemMedChem, 9(2), 337-349 (2014-01-01)

A novel SiX-dipropargyl glycerol scaffold (X: H, F, or (18) F) was developed as a versatile prosthetic group that provides technical advantages for the preparation of dimeric radioligands based on silicon fluoride acceptor pre- or post-labeling with fluorine-18. Rapid conjugation

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