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About This Item
Empirical Formula (Hill Notation):
C15H12N2O2
CAS Number:
Molecular Weight:
252.27
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
384532
grade
pharmaceutical primary standard
API family
phenytoin
manufacturer/tradename
USP
mp
293-295 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI
1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI key
CXOFVDLJLONNDW-UHFFFAOYSA-N
Gene Information
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Phenytoin USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Phenytoin Sodium
- Phenytoin Chewable Tablets
- Phenytoin Oral Suspension
- Phenytoin Sodium Injection
- Extended Phenytoin Sodium Capsules
- Phenytoin Compounded Topical Gel
- Fosphenytoin Sodium Injection
Biochem/physiol Actions
Anticonvulsant.
Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Disclaimer
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
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H Kamp et al.
Bioanalysis, 4(18), 2291-2301 (2012-10-11)
BASF and Metanomics have built-up the database MetaMap(®)-Tox containing rat plasma metabolome data for more than 500 reference compounds. Phenytoin was administered to five Wistar rats of both sexes at dietary dose levels of 600 and 2400 ppm over 28
Deborah Pugin et al.
Critical care (London, England), 18(3), R103-R103 (2014-06-03)
Seizures refractory to third-line therapy are also labeled super-refractory status epilepticus (SRSE). These seizures are extremely difficult to control and associated with poor outcome. We aimed to characterize efficacy and side-effects of continuous infusions of pentobarbital (cIV-PTB) treating SRSE. We
Precision, bias, and clinical utility of the Sheiner-Tozer equation to guide phenytoin dosing in critically ill adults.
Jennifer Bolt et al.
Journal of clinical pharmacology, 53(4), 451-455 (2013-02-26)
Katharine Gallop
Emergency medicine Australasia : EMA, 22(2), 108-118 (2010-06-11)
This article reviews the evidence regarding the use of phenytoin in adult and paediatric patients experiencing seizures in the ED in Australasia, including relevant pharmacokinetics, dosage, therapeutic drug monitoring and methods of administration. It summarizes current evidence regarding the use
Lelia Duley et al.
The Cochrane database of systematic reviews, (10)(10), CD000128-CD000128 (2010-10-12)
Eclampsia, the occurrence of a seizure in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants have been used to control eclamptic fits and to prevent further seizures. The objective of this review
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 1535008-200MG | 04061838740878 |
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