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1535507

USP

Phenytoin sodium

Name: Phenytoin sodium
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

5,5-Diphenylhydantoin sodium salt, 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin

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About This Item

Linear Formula:

C₁₅H₁₁N₂O₂Na

CAS Number:

630-93-3

Molecular Weight:

274.25

NACRES:

NA.24

PubChem Substance ID:

329750830

UNSPSC Code:

41116107

MDL number:

MFCD00069674

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Properties

grade

pharmaceutical primary standard

API family

phenytoin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3

InChI

1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1

InChI key

FJPYVLNWWICYDW-UHFFFAOYSA-M

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

Phenytoin sodium is an anti-epileptic drug, which belongs to the hydantoin family.

Application

Phenytoin sodium USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H317,H361

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

pcodes

P202 - P261 - P280 - P301 + P312 - P302 + P352 - P308 + P313

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Courtenay M and Griffiths M

Independent and Supplementary Prescribing: An Essential Guide null

Lemke.LT and Williams.AD

Foye's Principles of Medicinal Chemistry (2012)

Intraocular penetration of systemic antibiotics in eyes with penetrating ocular injury.

Shareef Ahmed et al.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 30(10), 823-830 (2014-08-29)

To determine whether penetrating scleral or corneal injury can enhance intraocular penetration of systemic moxifloxacin, vancomycin, and ceftazidime. Thirty rabbits were divided into 3 groups for each antibiotic and then further subdivided to receive either scleral or corneal injury to

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Global Trade Item Number

SKU	GTIN
1535507-200MG	04061838740915