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1568040

USP

Proguanil hydrochloride

Name: Proguanil hydrochloride
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Chlorguanide, N¹-(4-Chlorophenyl)-N⁵-isopropylbiguanide

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₆ClN₅·HCl

CAS Number:

637-32-1

Molecular Weight:

290.19

NACRES:

NA.24

PubChem Substance ID:

329750967

UNSPSC Code:

41116107

MDL number:

MFCD01732193

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grade

pharmaceutical primary standard

API family

proguanil

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1

InChI

1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H

InChI key

SARMGXPVOFNNNG-UHFFFAOYSA-N

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Related Categories

Pharmacopeia & Metrological Institute Standards

Analytical Reference Materials for Pharma QC

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Proguanil hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

Proguanil hydrochloride is antimalarial. Dihydrofolate reductase inhibitor

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P330 + P331 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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CYP2C19*17 increases clopidogrel-mediated platelet inhibition but does not alter the pharmacokinetics of the active metabolite of clopidogrel.

Rasmus Steen Pedersen et al.

Clinical and experimental pharmacology & physiology, 41(11), 870-878 (2014-08-15)

The aim of the present study was to determine the impact of CYP2C19*17 on the pharmacokinetics and pharmacodynamics of the active metabolite of clopidogrel and the pharmacokinetics of proguanil. Thus, we conducted an open-label two-phase cross-over study in 31 healthy

Global Trade Item Number

SKU	GTIN
1568040-200MG	04061833832660

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