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Merck
CN

1597005

USP

Quinine sulfate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Quinine hemisulfate salt monohydrate

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About This Item

Empirical Formula (Hill Notation):
C20H24N2O2 · 0.5H2O4S · H2O
CAS Number:
207671-44-1
Molecular Weight:
391.47
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329751013
MDL number:
MFCD00150790
Beilstein/REAXYS Number:
6113937

Key Documents

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Product Name

Quinine sulfate, United States Pharmacopeia (USP) Reference Standard

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

SMILES string

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI key

ZHNFLHYOFXQIOW-LPYZJUEESA-N

grade

pharmaceutical primary standard

API family

quinine

mol wt

monograph mol wt. 782.94

manufacturer/tradename

USP

mp

~225 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Quinine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Quinine Sulfate Capsules
  • Quinine Sulfate Tablets

Biochem/physiol Actions

Potassium channel blocker. Antimalarial
Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

General description

(C20H24N2O2)2 . H2SO4 . 2H2O
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Quinine sulfate is the sulfate salt of quinine, an alkaloid, obtained from the bark of Cinchona species.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Quinine sulfate
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 37(3), 3818-3818 (2018)
Determination of quinine sulfate in extemporaneous suspension by stability indicating high performance liquid chromatography
Jeadkong S, et al.
Research Journal of Pharmacy and Technology, 10(6), 1603-1610 (2017)

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