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1604610

USP

Risedronate sodium

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Risedronic acid monosodium salt hemi(pentahydrate)

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About This Item

Empirical Formula (Hill Notation):
C7H10NNaO7P2 · 2.5H2O
CAS Number:
329003-65-8
Molecular Weight:
350.13
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD01706268
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grade

pharmaceutical primary standard

API family

risedronate

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OP(C(P(O)([O-])=O)(O)CC1=CC=CN=C1)(O)=O.[Na+]

InChI

1S/2C7H11NO7P2.2Na.5H2O/c2*9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;;;;;;;/h2*1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);;;5*1H2/q;;2*+1;;;;;/p-2

InChI key

HYFDYHPNTXOPPO-UHFFFAOYSA-L

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General description

Risedronate sodium is a member of the pyridinyl class of bisphosphonates. It is mostly used as an antiresorptive agent. It can be used in treating and preventing postmenopausal and glucocorticoid-induced osteoporosis.

Application

Risedronate sodium USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Risedronate Sodium Tablets
  • Risedronate Sodium Delayed-Release Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - STOT SE 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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CUNHA F.
American Journal of Surgery, 76(3), 244-260 (1948)
Eliska Vaculikova et al.
Molecules (Basel, Switzerland), 19(11), 17848-17861 (2014-11-07)
One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low intestinal permeability. Eighteen samples of risedronate
Yoshihisa Hirota et al.
PloS one, 10(4), e0125737-e0125737 (2015-04-16)
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a significant role in vitamin K2 (MK-4) synthesis. We investigated the enzymological properties of UBIAD1 using microsomal fractions from Sf9 cells expressing UBIAD1 by analysing MK-4 biosynthetic activity. With regard to UBIAD1 enzyme
Jin Woo Park et al.
Archives of pharmacal research, 37(12), 1560-1569 (2013-11-21)
Risedronate is widely used clinically to treat osteoporosis, Paget's disease, hypercalcemia, bone metastasis, and multiple myeloma. However, its oral efficacy is restricted due to its low bioavailability and severe gastrointestinal adverse effects. This study was designed to evaluate the effect

Global Trade Item Number

SKUGTIN
1604610-350MG04061833861370

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