Product Name
Simethicone, United States Pharmacopeia (USP) Reference Standard
SMILES string
[Si](O[Si](C)(C)C)(OC)(C)C.[Si](=O)=O
InChI
1S/C6H18O2Si2.O2Si/c1-7-10(5,6)8-9(2,3)4;1-3-2/h1-6H3;
InChI key
AMTWCFIAVKBGOD-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
simethicone
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Simethicone USP reference standard suitable for use in specified USP compendial tests and assays.
Also used to prepare standard solutions for impurity analysis in Simethicone using the IR technique according to the United States Pharmacopeia (USP) monograph.
Also used to prepare standard solutions for impurity analysis in Simethicone using the IR technique according to the United States Pharmacopeia (USP) monograph.
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Simethicone comprises a combination of linear siloxane polymers that are fully methylated and consist of repeating units represented by the formula [–(CH3)2SiO–]n. The polymer is further stabilized using trimethylsiloxy end-blocking units denoted by the formula [(CH3)3SiO–], along with silicon dioxide.
Simethicone comprises a combination of linear siloxane polymers that are fully methylated and consist of repeating units represented by the formula [–(CH3)2SiO–]n. The polymer is further stabilized using trimethylsiloxy end-blocking units denoted by the formula [(CH3)3SiO–], along with silicon dioxide.
Other Notes
Sales restrictions may apply.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Stefano Pontone et al.
World journal of gastroenterology, 17(42), 4689-4695 (2011-12-20)
To investigate the effectiveness of low-volume plus ascorbic acid [polyethylene glycol plus ascorbic acid (PEG + Asc)] and high-volume plus simethicone [polyethylene glycol plus simethicone (PEG + Sim)] bowel preparations. A total of one hundred and forty-four outpatients (76 males)
Mihirani Balapatabendi et al.
Archives of disease in childhood, 96(9), 888-889 (2011-07-26)
Infacol (Forest Laboratories UK, Kent, UK) is a widely available over-the-counter preparation used to relieve colic symptoms in neonates and infants. The active ingredient is simeticone. No drug interactions with simeticone are documented in the current summary of product characteristics.
Hong-bin Chen et al.
Journal of clinical gastroenterology, 45(4), 337-341 (2010-09-28)
There is no consensus concerning small bowel preparation before capsule endoscopy (CE). This study evaluated the effects of 4 regimens on small bowel cleansing and diagnostic yield. Patients were randomly divided into 4 groups. Group A consumed a clear liquid
Simethicone
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 30(4), 4042-4042 (2020)
Sita V Jansen et al.
European journal of gastroenterology & hepatology, 23(10), 897-902 (2011-09-09)
A good bowel preparation is essential for optimal visualization of the large intestine. Several preparations with a difference in composition and volume are available. We compared five methods for bowel cleansing quality and patients' acceptability. Adult ambulatory outpatients scheduled for
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