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1642201

USP

Sumatriptan succinate

Name: Sumatriptan succinate
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):

3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate, GR-43175

Empirical Formula (Hill Notation):

C₁₄H₂₁N₃O₂S · C₄H₆O₄

CAS Number:

103628-48-4

Molecular Weight:

413.49

MDL number:

MFCD00902856

PubChem Substance ID:

329751213

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

sumatriptan

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1

InChI

1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

InChI key

PORMUFZNYQJOEI-UHFFFAOYSA-N

Gene Information

human ... HTR1B(3351) , HTR1D(3352)

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Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sumatriptan succinate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H361d - H412

Precautionary Statements

P202 - P273 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Aquatic Chronic 3 - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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[Anti-migraine drug sumatriptan succinate, a 5-HT1B/1D-receptor agonist].

Y Iwasawa et al.

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 117(6), 387-393 (2001-07-05)

Sumatriptan succinate (SMT) was a highly specific 5-HT1-receptor agonist. It showed high affinity only for 5-HT but no affinity for other neurotransmitter receptors such as muscarinic, dopamine D1, D2, adrenergic alpha 1, alpha 2, and beta. Furthermore, it was highly

Sumatriptan succinate : pharmacokinetics of different formulations in clinical practice.

Luana Lionetto et al.

Expert opinion on pharmacotherapy, 13(16), 2369-2380 (2012-09-28)

Migraine is a common neurovascular disorder characterized by recurrent episodes of disabling headache, autonomic nervous system dysfunction, and in some patients, neurological aura symptoms. Triptans are frequently prescribed drugs for the treatment of the acute migraine attack, considering their capability

5-HT7 receptors are involved in neurogenic dural vasodilatation in an experimental model of migraine.

Xiaojuan Wang et al.

Journal of molecular neuroscience : MN, 54(2), 164-170 (2014-03-04)

Neurogenic dural vasodilation has been demonstrated to play an important role in migraine. 5-HT(7) receptors have been found on trigeminal nerve endings and middle meningeal arteries and demonstrated involved in the dilatation of meningeal arteries. The aim of the present

Freeze drying: exploring potential in development of orodispersible tablets of sumatriptan succinate.

Dalapathi Gugulothu et al.

Drug development and industrial pharmacy, 41(3), 398-405 (2014-01-05)

The present investigation is aimed at development and characterization of sumatriptan succinate orodispersible tablets (ODTs) prepared by freeze drying technology. The tablet excipients were screened and the composition was optimized based on parameters which involved general appearance, tablet size and

Multidrug toxicity involving sumatriptan.

Jessica L Knittel et al.

Journal of analytical toxicology, 39(1), 75-79 (2014-10-18)

A multidrug fatality involving sumatriptan is reported. Sumatriptan is a tryptamine derivative that acts at 5-HT(1B/1D) receptors and is used for the treatment of migraines. The decedent was a 21-year-old white female found dead in bed by her spouse. No

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