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Merck
CN

1650006

USP

Tetracaine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H24N2O2 · HCl
CAS Number:
Molecular Weight:
300.82
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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Product Name

Tetracaine hydrochloride, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

SMILES string

Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI key

PPWHTZKZQNXVAE-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

tetracaine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Tetracaine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Benzocaine, Butamben, and Tetracaine Hydrochloride Gel
  • Benzocaine, Butamben, and Tetracaine Hydrochloride Ointment
  • Benzocaine, Butamben, and Tetracaine Hydrochloride Topical Aerosol®
  • Benzocaine, Butamben, and Tetracaine Hydrochloride Topical Solution
  • Lidocaine, Racepinephrine, and Tetracaine Hydrochlorides Compounded Topical Gel
  • Neomycin Sulfate, Isoflupredone Acetate, and Tetracaine Hydrochloride Ointment
  • Neomycin Sulfate, Isoflupredone Acetate, and Tetracaine Hydrochloride Topical Powder
Topical ophthalmic anesthetic; used for spinal anesthesia

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Legal Information

Aerosol is a registered trademark of Cytec Technology Corp.

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Genea Edwards et al.
Biochimie, 105, 99-109 (2014-07-12)
To identify the sphingolipid and ceramide species and their quantitative differences between normotensive and hypertensive intraocular pressure states in DBA/2J mouse aqueous humor (AH). Normotensive and hypertensive AH was sampled from mice by paracentesis. Lipid extraction was performed using modifications
Elisa Cinotti et al.
American journal of ophthalmology, 159(2), 324-333 (2014-12-03)
To evaluate whether the handheld in vivo reflectance confocal microscopy that has been recently developed for the study of skin tumors is suitable for the diagnosis of conjunctival tumors. Prospective study, observational case series. We prospectively evaluated the reflectance confocal
Sara Brittingham et al.
Investigative ophthalmology & visual science, 55(12), 8371-8376 (2014-12-04)
To compare the occurrence rate and depth of the demarcation line and topographical outcome after corneal cross-linking (CXL) for keratoconus using two different treatment protocols. A retrospective analysis of 131 eyes with progressive keratoconus treated with CXL using riboflavin and
Akihiro Tanaka et al.
Antimicrobial agents and chemotherapy, 58(8), 4380-4383 (2014-05-21)
We have reported significantly higher convulsion prevalence in patients treated with cefepime than in those treated with meropenem. Additionally, cefepime-associated convulsions were found only in patients with brain disorders, not renal failure. Here, we compared the convulsive liability of cefepime
Angel Nava-Castañeda et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(2), 106-113 (2014-11-05)
The aim of the study was to evaluate the effect of 3 subconjunctival bevacizumab injections in patients with an early corneal pterygium recurrence. This study was a nonrandomized single center trial. Patients with an early corneal pterygium recurrence were selected.

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