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Merck
CN

1A03810

USP

RIFAMYCIN O

Pharmaceutical Analytical Impurity (PAI)

Synonym(s):

Rifamycin O, (4-O-(Carboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-rifamycin gamma-Lactone)

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About This Item

Empirical Formula (Hill Notation):
C39H47NO14
CAS Number:
14487-05-9
Molecular Weight:
753.79
MDL number:
MFCD01683928
UNSPSC Code:
12352200
NACRES:
NA.24

Key Documents

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InChI key

RAFHKEAPVIWLJC-IQDWRYOJSA-N

InChI

1S/C39H47NO14/c1-17-11-10-12-18(2)37(48)40-24-15-39(51-16-26(42)53-39)29-27(33(24)46)32(45)22(6)35-28(29)36(47)38(8,54-35)50-14-13-25(49-9)19(3)34(52-23(7)41)21(5)31(44)20(4)30(17)43/h10-15,17,19-21,25,30-31,34,43-45H,16H2,1-9H3,(H,40,48)/b11-10-,14-13-,1

SMILES string

N1C2=CC5(OCC(=O)O5)c3c4c(c(c(c3C2=O)O)C)OC(O\C=C/C(C(C(C(C(C(C(C(\C=C/C=C(\C1=O)/C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C

grade

pharmaceutical analytical impurity (PAI)

agency

USP

manufacturer/tradename

USP

application(s)

pharmaceutical small molecule

format

neat

storage temp.

-10 to -25°C

Related Categories

General description

Rifamycin O is a USP Pharmaceutical Analytical Impurity (PAI).


USP PAI are a product line of impurities suitable for research and analytical purposes, which help to ensure the quality and safety of medicines.


Associated Drug Substance: Rifaximin


Therapeutic Area: Antibiotics

Application

Rifamycin O (USP PAI) is intended for use in analytical testing to detect, identify, and measure pharmaceutical impurities.

Features and Benefits

USP PAI advance your early analytical R&D and process development. PAI can be used in the following applications:
1. Conduct analytical tests during early formulation feasibility studies.
2. Determine degradation impurities produced during stress studies.
3. Develop, validate, and transfer analytical methods.
4. Perform spiking studies during process R&D to demonstrate depletion upon recrystallization.
5. Record retention times and/or spectra
6. Determine relative response factors.
7. Identify unknown impurities that formed during ICH stability conditions.
8. Identify impurities that are present in the Reference Listed Drug
9. Test for and profile impurities not listed in drug substance and drug product monographs.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  

Other Notes

Sales restrictions may apply.
USP issued SDS can be found here

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Warning

hcodes

H371,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 2

target_organs

Liver

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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