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Merck
CN

V900445

Vitamin B12

Vetec™, reagent grade, ≥98%

Synonym(s):

α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin

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About This Item

Empirical Formula (Hill Notation):
C63H88CoN14O14P
CAS Number:
68-19-9
Molecular Weight:
1355.37
UNSPSC Code:
12352205
PubChem Substance ID:
329829850
EC Number:
200-680-0
Beilstein/REAXYS Number:
4122889

Key Documents

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InChI key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

grade

reagent grade

product line

Vetec™

assay

≥98%

form

powder

technique(s)

HPLC: suitable

color

red to brown

storage temp.

2-8°C

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General description

Vitamin B12 is a water-soluble vitamin present in dietary sources including milk products, eggs, fish and meat. Vitamin B12, also called as cyanocobalamin, binds to protein transcobalamins. Structurally vitamin B12 has two pyrrole rings. The two forms comprise methylcobalamin or 5-deoxyadenosyl cobalamin, which are bioavailable.

Biochem/physiol Actions

Vitamin B12 plays a key role in DNA synthesis and methylation proteins. The intrinsic factor is essential for its circulation and reabsorption. Vitamin B12 coordinates with folic acid in the synthesis of red blood cells as well as in maintaining iron levels. It is essential for cellular energy production and serves as a cofactor for L-methyl malonyl-CoA mutase and methionine synthase. Vitamin B12 deficiency leads to pernicious anemia, megaloblastic anemia and neural tube defects.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD4816V
WXBD1071V
WXBC4719V
WXBC2768V
WXBC1614V

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Vitamin B12-A brief overview.
Goyal V
International archives of integrated medicine, 5(3), 30-35 (2015)
Vitamin B12 in health and disease
O Leary F and Samman S
Nutrients, 2(3), 299-316 (2010)
The metabolic processes of folic acid and Vitamin B12 deficiency
Mahmood L
Journal of Health Research and Reviews, 1(1), 5-5 (2014)
David Preiss et al.
The lancet. Diabetes & endocrinology, 2(2), 116-124 (2014-03-14)
Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes. We did a single-centre, double-blind, placebo-controlled trial at the Glasgow
Bamini Gopinath et al.
The American journal of clinical nutrition, 98(1), 129-135 (2013-05-03)
Epidemiologic evidence of a relation between serum total homocysteine (tHcy), vitamin B-12, and folate and age-related macular degeneration (AMD) is inconsistent and unresolved. In this cohort study, we aimed to investigate associations between intakes and serum concentrations of folate and
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