V900932
D-(+)-Trehalose dihydrate
Vetec™, reagent grade, ≥99%
Synonym(s):
D-(+)-Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
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About This Item
Empirical Formula (Hill Notation):
C12H22O11 · 2H2O
CAS Number:
Molecular Weight:
378.33
EC Number:
202-739-6
UNSPSC Code:
12352201
PubChem Substance ID:
Beilstein/REAXYS Number:
5322018
MDL number:
InChI key
DPVHGFAJLZWDOC-PVXXTIHASA-N
InChI
1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
SMILES string
[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
grade
reagent grade
product line
Vetec™
assay
≥99%
form
powder
storage temp.
room temp
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Application
- Spray-dried microparticles of encapsulated gefitinib for slow-release localized treatment of periodontal disease.: This study explores the development of spray-dried microparticles encapsulating gefitinib using D-(+)-Trehalose dihydrate for slow-release treatment of periodontal disease. The research highlights the potential of this method to provide localized, sustained drug delivery, which can enhance the therapeutic efficacy and reduce systemic side effects (Baldelli et al., 2023).
- On the particle formation of leucine in spray drying of inhalable microparticles.: This research examines the particle formation mechanisms during the spray drying of leucine to create inhalable microparticles. It provides insights into the role ofD-(+)-Trehalose dihydrate in stabilizing the particles and improving their aerosolization properties, which are critical for the development of effective inhalation therapies (Ordoubadi et al., 2021).
Other Notes
To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
涉药品监管产品
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Sabine Ullrich et al.
Journal of pharmaceutical sciences, 104(6), 2040-2046 (2015-04-03)
The importance of cake adhesion to the inside vial wall during lyophilization of amorphous trehalose cakes was determined by using hydrophobized vials. The degrees of cake shrinkage and cracking were determined independently by photographic imaging of the cake top surface
Alan Twomey et al.
International journal of pharmaceutics, 487(1-2), 91-100 (2015-04-19)
In frozen and lyophilized systems, the biological to be stabilized (e.g. therapeutic protein, biomarker, drug-delivery vesicle) and the cryo-/lyo-protectant should be co-localized for successful stabilization. During freezing and drying, many factors cause physical separation of the biological from the cryo-/lyo-protectant
Joachim Schaefer et al.
International journal of pharmaceutics, 489(1-2), 124-130 (2015-05-06)
The inactivation of catalase during spray-drying over a range of outlet gas temperatures could be closely represented by the Arrhenius equation. From this an activation energy for damage to the catalase could be calculated. The close fit to Arrhenius suggests
Sabine Ullrich et al.
Pharmaceutical research, 32(8), 2503-2515 (2015-02-06)
Measurement of the kinetic development of shrinkage and cracking of an amorphous trehalose cake as they take place during lyophilization. A novel technique has been developed which monitors a vial in situ during the freeze-drying cycle. The 2-dimensional degrees of
Anke Sass et al.
Drug development and industrial pharmacy, 40(6), 749-757 (2013-04-20)
The spray-drying behaviour of 16 water-miscible organic solvents on a bench-scale machine (Büchi B290 with inert loop) was determined under mild-to-moderate process conditions, namely inlet gas temperature of 130 °C and liquid feed flow rate of ≤3 mL/min. The solvents with boiling
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