Merck
CN

PDE4A

phosphodiesterase 4A, cAMP-specific

别名:
DPDE2, PDE4, PDE46
物种:
Human PDE4A (5141), Mouse Pde4a (18577), Rat Pde4a (25638), sheep PDE4A (101117505), Domestic Rabbit PDE4A (100009247), Zebrafish pde4a (572061), domestic cat PDE4A (751107), dog PDE4A (100683695), chicken PDE4A (769860), domestic guinea pig Pde4a (100135594) ...展开
UniProtKB ID:
P27815, O75522, O76092, Q16255, Q16691, Q5DM53, Q6PMT2, Q8IVA7
基因ID:
  • Human(5141) Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
  • Mouse(18577) phosphodiesterase 4A, cAMP specific
  • Rat(25638) phosphodiesterase 4A, cAMP-specific
  • sheep(101117505) phosphodiesterase 4A, cAMP-specific
  • Domestic Rabbit(100009247) phosphodiesterase 4A, cAMP-specific
  • Zebrafish(572061) phosphodiesterase 4A, cAMP-specific
  • domestic cat(751107) phosphodiesterase 4A, cAMP-specific
  • dog(100683695) phosphodiesterase 4A, cAMP-specific
  • chicken(769860) phosphodiesterase 4A, cAMP-specific
  • domestic guinea pig(100135594) phosphodiesterase 4A, cAMP-specific
  • cow(512222) phosphodiesterase 4A, cAMP-specific
  • naked mole-rat(101717168) phosphodiesterase 4A, cAMP-specific

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Small Molecule - Activator

货号
说明
物种
R6520
咯利普兰, solid, ≥98% (HPLC),
物种
human, mouse, rat

Small Molecule - Antagonist

货号
说明
物种
B8279
4-（3-丁氧基-4-甲氧基苄基）咪唑烷-2-酮, solid,
物种
human, rat
R6520
咯利普兰, solid, ≥98% (HPLC),
物种
human, mouse, rat
D9766
双嘧达莫, ≥98% (HPLC),
物种
mouse, human

Antibodies

货号
说明
物种反应性
应用
HPA076091
Anti-PDE4A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
HPA043310
Anti-PDE4A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
SAB1410926
Anti-PDE4A antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot

Small Molecule - Inhibitor

货号
说明
物种
SML1099
罗氟司特, ≥98% (HPLC),
物种
human
Z0878
敏喘宁, solid,
物种
human
C7971
环己喹酰胺, phosphodiesterase inhibitor,
物种
rat, human
B8279
4-（3-丁氧基-4-甲氧基苄基）咪唑烷-2-酮, solid,
物种
human, rat
BP571
黄酮哌酯 盐酸盐, British Pharmacopoeia (BP) Reference Standard,
物种
human

Proteins

货号
说明
物种
SRP0430
PDE4A4B active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE),
物种
human
SRP0429
PDE4A10 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE),
物种
human
SRP0262
PDE4A1A Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
物种
human

esiRNA

货号
说明
物种
EMU021261
MISSION® esiRNA, targeting mouse Pde4a,
物种
mouse
EHU096631
MISSION® esiRNA, targeting human PDE4A (2),
物种
human
EHU141671
MISSION® esiRNA, targeting human PDE4A (3),
物种
human
EHU088881
MISSION® esiRNA, targeting human PDE4A,
物种
human