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I0157

Ibudilast

≥99% (HPLC), Phosphodiesterase IV inhibitor, solid

别名:

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404

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关于此项目

经验公式（希尔记法）:
C14 H18 N2 O
化学文摘社编号:
50847-11-5
分子量:
230.31
UNSPSC Code:
41106305
PubChem Substance ID:
24278482
NACRES:
NA.77
MDL number:
MFCD00864808
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
200
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产品名称

Ibudilast, ≥99% (HPLC), solid

Quality Level

200

assay

≥99% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 28 mg/mL, H2O: soluble 4.5 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)C(=O)c1c(nn2ccccc12)C(C)C

InChI

1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

InChI key

ZJVFLBOZORBYFE-UHFFFAOYSA-N

Gene Information

human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

相关类别

Biochem/physiol Actions

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000536625
0000536620
0000536625
0000536620
0000511227

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Primary neuroprotection: the Holy Grail of multiple sclerosis therapy.
Robert J Fox
Neurology, 74(13), 1018-1019 (2010-03-05)
F Barkhof et al.
Neurology, 74(13), 1033-1040 (2010-03-05)
Ibudilast is a phosphodiesterase inhibitor influencing inflammation and neurodegeneration in multiple sclerosis (MS). This study evaluated the safety, tolerability, and effects on MRI parameters of 2 different doses of ibudilast in relapsing forms of MS. In this multicenter, double-blind, phase
Masahiro Noguchi et al.
Biological & pharmaceutical bulletin, 32(11), 1924-1927 (2009-11-03)
Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal
Aldric T Hama et al.
Journal of neurotrauma, 29(3), 600-610 (2011-08-03)
Ibudilast, an asthma drug, has demonstrated antinociceptive effects in several rat models of peripheral neuropathic pain, and a proposed mechanism of action is the inhibition of release of the cytokine tumor necrosis factor-α (TNF-α) from activated spinal microglia. Spinal glial
Hwa Yoon et al.
Biomedical chromatography : BMC, 24(3), 324-328 (2009-07-25)
A simple, accurate, precise and cost effective reversed-phase HPLC method was developed to determine the concentration of ibudilast in human serum. Ibudilast and an internal standard, butyl 4-hydroxybenzoate, were extracted by liquid-liquid extraction with methyl tert-butyl ether. HPLC analysis was
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全球贸易项目编号

货号GTIN
I0157-10MG04061833271643
I0157-50MG04061833271650

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