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Merck
CN

C4780

辅酶 A 钠盐 水合物

suitable for cell culture, BioReagent

别名:

CoA Na2

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关于此项目

经验公式（希尔记法）:
C21H36N7O16P3S · xNa+ · yH2O
化学文摘社编号:
55672-92-9
分子量:
767.53 (anhydrous free acid basis)
MDL number:
MFCD00079020
UNSPSC Code:
12352205
PubChem Substance ID:
24892723
EC Number:
259-747-8
NACRES:
NA.75

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产品名称

辅酶 A 钠盐 水合物, suitable for cell culture, BioReagent

InChI

1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H

InChI key

SYTRWOCXZXQBPW-CLVRNSBASA-M

SMILES string

[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS

biological source

yeast

description

cofactor for acyl transfer

product line

BioReagent

assay

≥85% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

Quality Level

200

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Analysis Note

使用磷酸转乙酰酶酶促测定。约 95％ CoA-SH

Application

辅酶 A 钠盐水合物已用于：
  • 支链氨基转移酶测定和蛋白质测定
  • 吡咯基-S-Bmp1（酰基载体蛋白（ACP）-硫酯酶（TE）二结构域蛋白）被 Bmp2 卤化的测定中
  • 作为细胞外辅酶 A（CoA），在体外和体内实验中研究细胞和生物体获得 CoA 的替代途径

Biochem/physiol Actions

辅酶 A（CoA）是一种普遍存在的辅因子，在许多代谢途径中发挥着重要作用，主要是作为酰基辅酶 A。它对三羧酸循环以及脂肪酸的合成和氧化至关重要。辅酶 A 促进酰基转移，特别是在脂肪酸和脂质代谢反应中的酰基转移。它与神经退行性变、自噬、蛋白质乙酰化和信号传导有关。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000327392
0000327392
0000420099
0000420113
0000420113

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Balaji Srinivasan et al.
Nature chemical biology, 11(10), 784-792 (2015-09-01)
The metabolic cofactor coenzyme A (CoA) gained renewed attention because of its roles in neurodegeneration, protein acetylation, autophagy and signal transduction. The long-standing dogma is that eukaryotic cells obtain CoA exclusively via the uptake of extracellular precursors, especially vitamin B5
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Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria freshly isolated from tissue, along with examples to assess the potency and specificity
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Cell stem cell, 27(3), 441-458 (2020-07-02)
Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process

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