C4780
辅酶 A 钠盐 水合物
suitable for cell culture, BioReagent
别名:
CoA Na2
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关于此项目
经验公式（希尔记法）:
C21H36N7O16P3S · xNa+ · yH2O
化学文摘社编号:
分子量:
767.53 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
12352205
PubChem Substance ID:
EC Number:
259-747-8
NACRES:
NA.75
InChI
1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H
InChI key
SYTRWOCXZXQBPW-CLVRNSBASA-M
SMILES string
[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
biological source
yeast
Quality Level
product line
BioReagent
assay
≥85% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
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Application
辅酶 A 钠盐水合物已用于：
- 支链氨基转移酶测定和蛋白质测定
- 吡咯基-S-Bmp1（酰基载体蛋白（ACP）-硫酯酶（TE）二结构域蛋白）被 Bmp2 卤化的测定中
- 作为细胞外辅酶 A（CoA），在体外和体内实验中研究细胞和生物体获得 CoA 的替代途径
Biochem/physiol Actions
辅酶 A（CoA）是一种普遍存在的辅因子，在许多代谢途径中发挥着重要作用，主要是作为酰基辅酶 A。它对三羧酸循环以及脂肪酸的合成和氧化至关重要。辅酶 A 促进酰基转移，特别是在脂肪酸和脂质代谢反应中的酰基转移。它与神经退行性变、自噬、蛋白质乙酰化和信号传导有关。
Analysis Note
使用磷酸转乙酰酶酶促测定。约 95％ CoA-SH
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Balaji Srinivasan et al.
Nature chemical biology, 11(10), 784-792 (2015-09-01)
The metabolic cofactor coenzyme A (CoA) gained renewed attention because of its roles in neurodegeneration, protein acetylation, autophagy and signal transduction. The long-standing dogma is that eukaryotic cells obtain CoA exclusively via the uptake of extracellular precursors, especially vitamin B5
Yongzhong Wei et al.
World journal of gastroenterology, 14(2), 193-199 (2008-01-12)
Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD
Yao Rong et al.
eLife, 10 (2021-08-20)
TMEM120A, a member of the transmembrane protein 120 (TMEM120) family, has a pivotal function in adipocyte differentiation and metabolism, and may also contribute to sensing mechanical pain by functioning as an ion channel named TACAN. Here we report that expression
Krista Yang et al.
STAR protocols, 2(3), 100687-100687 (2021-08-18)
Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria freshly isolated from tissue, along with examples to assess the potency and specificity
Le Tran Phuc Khoa et al.
Cell stem cell, 27(3), 441-458 (2020-07-02)
Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process
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