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103276

哈尔满碱

Name: 哈尔满碱
Brand: ALDRICH

98%

别名:

1-甲基-9H-吡啶并[3,4-b]吲哚, 2-甲基-β-咔啉, 阿锐碱

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₀N₂

化学文摘社编号:

486-84-0

分子量:

182.22

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24846602

EC Number:

207-642-2

Beilstein/REAXYS Number:

143898

MDL number:

MFCD00004957

Assay:

98%

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属性

Quality Level

100

assay

98%

drug control

stupéfiant (France)

mp

235-238 °C (lit.)

solubility

methanol: soluble 50mg/ml

SMILES string

Cc1nccc2c3ccccc3[nH]c12

InChI

1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3

InChI key

PSFDQSOCUJVVGF-UHFFFAOYSA-N

Gene Information

human ... CYP2D6(1565)
rat ... Gabra2(29706)

说明

General description

Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
Blood harmane concentration is elevated in essential tremor, late-life neurological disease.

Application

Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
It was used to study interactions of norharman and harman with DNA.
It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

Biochem/physiol Actions

I₁ 咪唑啉结合位点激动剂。

Preparation Note

Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315

pcodes

P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364

Hazard Classifications

Acute Tox. 4 Oral - Skin Irrit. 2

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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实验方案

Mass Spectrometry of Glycans

Explore mass spectrometry analysis of glycans for glycomic & glycoproteomic neutral & acidic glycan analysis. See a general mass spec glycan analysis procedure.

聚糖的质谱

该聚糖质谱分析方案，被称之为干液滴法，基于原始的MALDI实验并依然是MS领域中最常用的方法。

Interactions of norharman and harman with DNA.

K Hayashi et al.

Nucleic acids research, 4(11), 3679-3685 (1977-11-01)

The interactions of norharman (9H-pyrido [3,4-b] indole) and harman (1-methyl-9H-pyrido [3,4-b] indole) with DNA were studied. DNA caused remarkable fluorescence quenching and change in the absorption spectra of the dyes. Scatchard plots obtained by optical titration gave Kd values of

Modulation of prototropic activity and rotational relaxation dynamics of a cationic biological photosensitizer within the motionally constrained bio-environment of a protein.

Bijan Kumar Paul et al.

The journal of physical chemistry. B, 115(34), 10322-10334 (2011-07-28)

The present work describes the interaction of a promising cancer cell photosensitizer, harmane (HM), with a model transport protein, Bovine Serum Albumin (BSA). The studied molecule of interest (HM) belongs to the family of naturally occurring fluorescent drug-binding alkaloids, the

Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking.

Ingrid Bacher et al.

Archives of general psychiatry, 68(8), 817-826 (2011-08-04)

Greater prefrontal cortex and anterior cingulate cortex monoamine oxidase A (MAO-A) binding is associated with depressed mood. Substances in cigarette smoke, such as harman, inhibit MAO-A, and cigarette withdrawal is associated with depressed mood. Dysphoria during cigarette withdrawal predicts relapse.

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全球贸易项目编号

货号	GTIN
103276-1G	04061838670441