质量水平
方案
98%
mp
110 °C (dec.) (lit.)
官能团
amide
SMILES字符串
NC(=O)c1ccccn1
InChI
1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)
InChI key
IBBMAWULFFBRKK-UHFFFAOYSA-N
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应用
以吡啶酰胺为模板制备分子印迹聚合物 。在一项研究中，吡啶酰胺被用于评估吡啶酰胺从HClO 4 中的铬（III） - 吡啶酰胺络合物中释放的动力学和机理。
生化/生理作用
吡啶酰胺是大鼠胰岛细胞核多聚（ADP-核糖）合成酶的潜在抑制剂 。吡啶酰胺充当二齿配体并与镧系元素硝酸盐，硫氰酸盐和高氯酸盐形成配合物。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Hongguang Liu et al.
Journal of medicinal chemistry, 56(3), 895-901 (2013-01-11)
Melanoma is an aggressive skin cancer with worldwide increasing incidence. Development of positron emission tomography (PET) probes for early detection of melanoma is critical for improving the survival rate of melanoma patients. In this research, (18)F-picolinamide-based PET probes were prepared
T Kawabata et al.
Acta pathologica japonica, 42(7), 469-475 (1992-07-01)
The effects of three isomers of pyridinecarboxamide (picolinamide (2-pyridinecarboxamide), nicotinamide (3-pyridinecarboxamide) and isonicotinamide (4-pyridinecarboxamide)) on iron-induced renal damage were studied. Pyridinecarboxamide (250 mg/kg body weight, ip) was administered 10 min before injection of ferric nitrilotriacetate (Fe(III)-NTA) (7.5 mgFe/kg body weight
Manuela Jörg et al.
ChemMedChem, 16(1), 216-233 (2020-08-28)
This study investigated the structure-activity relationships of 4-phenylpyridin-2-one and 6-phenylpyrimidin-4-one M1 muscarinic acetylcholine receptor (M1 mAChRs) positive allosteric modulators (PAMs). The presented series focuses on modifications to the core and top motif of the reported leads, MIPS1650 (1) and MIPS1780
Mark Turlington et al.
Journal of medicinal chemistry, 56(20), 7976-7996 (2013-09-21)
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Both allosteric agonism and high glutamate fold-shift have been implicated in the neurotoxic profile of some mGlu5 PAMs; however, these
Hemant Bhutani et al.
Journal of pharmaceutical and biomedical analysis, 39(5), 892-899 (2005-06-28)
Rifampicin and isoniazid are known to interact with each other in solid formulation environment to yield isonicotinyl hydrazone (HYD). In earlier studies, this reaction was indicated to be catalyzed by pyrazinamide and ethambutol hydrochloride, the two other co-drugs present in
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