产品名称
吡啶酰胺, 98%
InChI key
IBBMAWULFFBRKK-UHFFFAOYSA-N
InChI
1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)
SMILES string
NC(=O)c1ccccn1
assay
98%
mp
110 °C (dec.) (lit.)
functional group
amide
Quality Level
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Application
以吡啶酰胺为模板制备分子印迹聚合物 。在一项研究中,吡啶酰胺被用于评估吡啶酰胺从HClO 4 中的铬(III) - 吡啶酰胺络合物中释放的动力学和机理。
Biochem/physiol Actions
吡啶酰胺是大鼠胰岛细胞核多聚(ADP-核糖)合成酶的潜在抑制剂 。吡啶酰胺充当二齿配体并与镧系元素硝酸盐,硫氰酸盐和高氯酸盐形成配合物。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Bambang Kuswandi et al.
Analytica chimica acta, 591(2), 208-213 (2007-05-08)
A disposable ion-selective optode for mercury based on trityl-picolinamide (T-Pico) as neutral ionophore was developed. The sensing layer consist of plasticised PVC incorporating T-Pico as a selective ionophore for Hg2+, ETH 5418 as a chromoionophore, and potassium tetrakis[3,5-bis(trifluoromethyl)phenyl] borate as
Jeremy L Yap et al.
Organic & biomolecular chemistry, 10(15), 2928-2933 (2012-03-08)
By conducting a structure-activity relationship study of the backbone of a series of oligoamide-foldamer-based α-helix mimetics of the Bak BH3 helix, we have identified especially potent inhibitors of Bcl-x(L). The most potent compound has a K(i) value of 94 nM
Ryan A Olsen et al.
Journal of the American Chemical Society, 125(33), 10125-10132 (2003-08-14)
Pyridine carboxamides are a class of medicinal agents with activity that includes the reduction of iron-induced renal damage, the regulation of nicotinamidase activity, and radio- and chemosensitization. Such pharmacological activities, and the prevalence of the carboxamide moiety and the importance
Hongguang Liu et al.
Journal of medicinal chemistry, 56(3), 895-901 (2013-01-11)
Melanoma is an aggressive skin cancer with worldwide increasing incidence. Development of positron emission tomography (PET) probes for early detection of melanoma is critical for improving the survival rate of melanoma patients. In this research, (18)F-picolinamide-based PET probes were prepared
T Kawabata et al.
Acta pathologica japonica, 42(7), 469-475 (1992-07-01)
The effects of three isomers of pyridinecarboxamide (picolinamide (2-pyridinecarboxamide), nicotinamide (3-pyridinecarboxamide) and isonicotinamide (4-pyridinecarboxamide)) on iron-induced renal damage were studied. Pyridinecarboxamide (250 mg/kg body weight, ip) was administered 10 min before injection of ferric nitrilotriacetate (Fe(III)-NTA) (7.5 mgFe/kg body weight
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