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Merck
CN

106615

2,2-双(羟甲基)丙酸

98%

别名:

Bis-MPA, DMPA®, 二羟甲基丙酸

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关于此项目

线性分子式:
(HOCH2)2C(CH3)COOH
化学文摘社编号:
分子量:
134.13
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
225-306-3
Beilstein/REAXYS Number:
1756385
MDL number:
Assay:
98%
Form:
solid
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vapor density

<1 (vs air)

Quality Level

assay

98%

form

solid

mp

189-191 °C (lit.)

solubility

H2O: soluble, acetone: slightly soluble, benzene: insoluble, methanol: soluble

functional group

carboxylic acid, hydroxyl

SMILES string

CC(CO)(CO)C(O)=O

InChI

1S/C5H10O4/c1-5(2-6,3-7)4(8)9/h6-7H,2-3H2,1H3,(H,8,9)

InChI key

PTBDIHRZYDMNKB-UHFFFAOYSA-N

Application

2,2-双(羟甲基)丙酸用于聚甲基硅氧烷(Si-PUD)改性聚氨酯分散体的合成和表征研究及其与粘土结合的纳米复合材料。2,2-双(羟甲基)丙酸基树枝状大分子在作为顺铂和多柔比星等强效抗癌药物的递送系统以及硼中子俘获疗法和光动力疗法的药剂方面具有很大的应用价值
2,2-双(羟甲基)丙酸通常用作AB2 单体,用于合成超支化(hb)聚合物和树枝状大分子。
以2,2-双(羟甲基)丙酸合成了具有48个羟基的第四代三分枝树枝状大分子。
该酸简单衍生后就可通过“点击”叠氮-炔环加成反应来构建树枝状结构。

Legal Information

DMPA is a registered trademark of GEO Specialty Chemicals, Inc.


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Kazuki Fukushima et al.
Biomaterials science, 7(6), 2288-2296 (2019-04-25)
Cationic aliphatic polycarbonates bearing primary ammonium side chains have been developed with relatively high molecular weights and controlled macromolecular architectures. These polycarbonates exhibit reasonable antimicrobial activity against Gram-negative and Gram-positive bacteria. The prepared homopolymers could be effective against Gram-negative bacteria
First divergent strategy using two AB2 unprotected monomers for the rapid synthesis of dendrimers.
Brauge L, et al.
Journal of the American Chemical Society, 123(27), 6698-6699 (2001)
Elizabeth R Gillies et al.
Drug discovery today, 10(1), 35-43 (2005-01-29)
The unique properties of dendrimers, such as their high degree of branching, multivalency, globular architecture and well-defined molecular weight, make them promising new scaffolds for drug delivery. In the past decade, research has increased on the design and synthesis of



全球贸易项目编号

货号GTIN
106615-100G04061838674272
106615-3KG04061838674296
106615-500G04061838674302
106615-12KG04061838674289